Competence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherence

• Vikrant Minhas ,

  Contributed equally to this work with: Vikrant Minhas, Arnau Domenech, Dimitra Synefiaridou

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Biophore Building, Lausanne, Switzerland

  https://orcid.org/0000-0002-2750-4677

  ⨯
• Arnau Domenech ,

  Contributed equally to this work with: Vikrant Minhas, Arnau Domenech, Dimitra Synefiaridou

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Biophore Building, Lausanne, Switzerland

  https://orcid.org/0000-0002-0829-511X

  ⨯
• Dimitra Synefiaridou ,

  Contributed equally to this work with: Vikrant Minhas, Arnau Domenech, Dimitra Synefiaridou

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Biophore Building, Lausanne, Switzerland

  https://orcid.org/0000-0002-4868-307X

  ⨯
• Daniel Straume,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway

  https://orcid.org/0000-0002-5222-9275

  ⨯
• Max Brendel,

  Roles Investigation

  Affiliation Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, Universität Greifswald, Greifswald, Germany

  ⨯
• Gonzalo Cebrero,

  Roles Investigation

  Affiliation Biozentrum, University of Basel, Basel, Switzerland

  https://orcid.org/0000-0001-7171-0921

  ⨯
• Xue Liu,

  Roles Conceptualization, Data curation, Methodology

  Affiliations Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Biophore Building, Lausanne, Switzerland, Guangdong Key Laboratory for Genome Stability and Human Disease Prevention, Department of Pharmacology, International Cancer Center, Shenzhen University Health Science Center, Shenzhen, China

  https://orcid.org/0000-0001-6485-1865

  ⨯
• Charlotte Costa,

  Roles Investigation

  Affiliation Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, Lille, France

  https://orcid.org/0000-0002-2772-0185

  ⨯
• Mara Baldry,

  Roles Investigation

  Affiliation Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, Lille, France

  https://orcid.org/0000-0001-6005-1078

  ⨯
• Jean-Claude Sirard,

  Roles Methodology, Writing – review & editing

  Affiliation Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, Lille, France

  https://orcid.org/0000-0001-9854-4652

  ⨯
• Camilo Perez,

  Roles Methodology, Writing – review & editing

  Affiliation Biozentrum, University of Basel, Basel, Switzerland

  https://orcid.org/0000-0002-5800-0084

  ⨯
• Nicolas Gisch,

  Roles Methodology, Writing – review & editing

  Affiliation Division of Bioanalytical Chemistry, Priority Area Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany

  https://orcid.org/0000-0003-3260-5269

  ⨯
• Sven Hammerschmidt,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, Universität Greifswald, Greifswald, Germany

  https://orcid.org/0000-0002-6382-6681

  ⨯
• Leiv Sigve Håvarstein ,

  Roles Conceptualization, Supervision, Writing – review & editing

  * E-mail: sigve.havarstein@nmbu.no (LSH); jan-willem.veening@unil.ch (J-WV)

  Affiliation Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway

  https://orcid.org/0000-0001-8250-4322

  ⨯
• Jan-Willem Veening

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft

  * E-mail: sigve.havarstein@nmbu.no (LSH); jan-willem.veening@unil.ch (J-WV)

  Affiliation Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Biophore Building, Lausanne, Switzerland

  https://orcid.org/0000-0002-3162-6634

  ⨯