An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets

• Natalia Moskal,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Biochemistry, University of Toronto, Toronto, Canada

  ⨯
• Naomi P. Visanji,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Edmund J Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Canada

  ⨯
• Olena Gorbenko,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biochemistry, University of Toronto, Toronto, Canada

  ⨯
• Vijay Narasimhan,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Zebrafish Centre for Advanced Drug Discovery and Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital and Department of Medicine and Physiology, University of Toronto, Toronto, Canada

  ⨯
• Hannah Tyrrell,

  Roles Investigation

  Affiliation Department of Biochemistry, University of Toronto, Toronto, Canada

  ⨯
• Jess Nash,

  Roles Investigation

  Affiliation Department of Biochemistry, University of Toronto, Toronto, Canada

  ⨯
• Peter N. Lewis,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Biochemistry, University of Toronto, Toronto, Canada

  ⨯
• G. Angus McQuibban

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: angus.mcquibban@utoronto.ca

  Affiliation Department of Biochemistry, University of Toronto, Toronto, Canada

  https://orcid.org/0000-0002-1126-922X

  ⨯