Mechanism of agonist-induced activation of the human itch receptor MRGPRX1

• Bing Gan ,

  Contributed equally to this work with: Bing Gan, Leiye Yu, Haifeng Yang

  Roles Investigation, Writing – review & editing

  Affiliations Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China, The Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong, China

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• Leiye Yu ,

  Contributed equally to this work with: Bing Gan, Leiye Yu, Haifeng Yang

  Roles Investigation, Writing – review & editing

  Affiliation Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China

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• Haifeng Yang ,

  Contributed equally to this work with: Bing Gan, Leiye Yu, Haifeng Yang

  Roles Investigation

  Affiliations State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China, Shenzhen Research Institute, Wuhan University, Shenzhen, China

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• Haizhan Jiao,

  Roles Investigation

  Affiliation The Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong, China

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• Bin Pang,

  Roles Investigation

  Affiliation Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China

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• Yian Chen,

  Roles Investigation

  Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China

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• Chen Wang,

  Roles Investigation

  Affiliation Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China

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• Rui Lv,

  Roles Investigation

  Affiliation Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China

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• Hongli Hu,

  Roles Validation

  Affiliation The Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong, China

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• Zhijian Cao ,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: zjcao@whu.edu.cn (ZC); renruobing@fudan.edu.cn (RR)

  Affiliations State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China, Shenzhen Research Institute, Wuhan University, Shenzhen, China

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• Ruobing Ren

  Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: zjcao@whu.edu.cn (ZC); renruobing@fudan.edu.cn (RR)

  Affiliations Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China, Shanghai Qi Zhi Institute, Shanghai, China

  https://orcid.org/0000-0003-4517-7216

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