Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs

• Lipin Loo ,

  Contributed equally to this work with: Lipin Loo, Matthew A. Waller

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Charles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, Centenary Institute, and School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales, Australia

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• Matthew A. Waller ,

  Contributed equally to this work with: Lipin Loo, Matthew A. Waller

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Charles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, Centenary Institute, and School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales, Australia

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• Cesar L. Moreno,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Charles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, Centenary Institute, and School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales, Australia

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• Alexander J. Cole,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliation Centenary Institute and Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia

  ⨯
• Alberto Ospina Stella,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliation The Kirby Institute, University of New South Wales, New South Wales, Australia

  ⨯
• Oltin-Tiberiu Pop,

  Roles Investigation, Methodology, Validation, Visualization

  Affiliation Institute for Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland

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• Ann-Kristin Jochum,

  Roles Investigation, Methodology, Validation, Visualization

  Affiliations Institute for Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland, Institute for Pathology, Kantonsspital St. Gallen, St. Gallen, Switzerland

  ⨯
• Omar Hasan Ali,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Institute for Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland, Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada, Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

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• Christopher E. Denes,

  Roles Investigation, Methodology, Validation

  Affiliation Charles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, Centenary Institute, and School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales, Australia

  ⨯
• Zina Hamoudi,

  Roles Formal analysis, Investigation, Methodology, Validation

  Affiliation Charles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, Centenary Institute, and School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales, Australia

  ⨯
• Felicity Chung,

  Roles Investigation, Methodology

  Affiliation Charles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, Centenary Institute, and School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales, Australia

  ⨯
• Anupriya Aggarwal,

  Roles Investigation, Methodology

  Affiliation The Kirby Institute, University of New South Wales, New South Wales, Australia

  ⨯
• Jason K. K. Low,

  Roles Methodology

  Affiliation School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia

  ⨯
• Karishma Patel,

  Roles Methodology

  Affiliation School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia

  ⨯
• Rezwan Siddiquee,

  Roles Methodology

  Affiliation School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia

  ⨯
• Taeyoung Kang,

  Roles Methodology

  Affiliation Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia

  ⨯
• Suresh Mathivanan,

  Roles Methodology

  Affiliation Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia

  ⨯
• Joel P. Mackay,

  Roles Methodology

  Affiliation School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia

  ⨯
• Wolfram Jochum,

  Roles Formal analysis, Investigation, Resources, Supervision, Validation, Visualization

  Affiliation Institute for Pathology, Kantonsspital St. Gallen, St. Gallen, Switzerland

  ⨯
• Lukas Flatz,

  Roles Investigation, Methodology, Resources, Validation, Visualization

  Affiliations Institute for Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland, Center for Dermatooncology, Department of Dermatology, Eberhard Karls University of Tübingen, Tübingen, Germany

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• Daniel Hesselson,

  Roles Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft

  Affiliation Centenary Institute and Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia

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• Stuart Turville,

  Roles Investigation, Methodology, Project administration, Resources, Supervision

  Affiliation The Kirby Institute, University of New South Wales, New South Wales, Australia

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•  [ ... ],
• G. Gregory Neely

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: greg.neely@sydney.edu.au

  Affiliation Charles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, Centenary Institute, and School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales, Australia

  https://orcid.org/0000-0002-1957-9732

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