Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus

• Steven F. Baker ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: sbaker@lovelacebiomedical.org (SFB); amehle@wisc.edu (AM)

  Current address: Lovelace Biomedical Research Institute, Albuquerque, New Mexico, United Sates of America

  Affiliation Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  https://orcid.org/0000-0001-8379-283X

  ⨯
• Helene Meistermann,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Roche Pharma Research and Early Development, Pharmaceutical Sciences–Biomarkers, Bioinformatics and Omics & Pathology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

  ⨯
• Manuel Tzouros,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Roche Pharma Research and Early Development, Pharmaceutical Sciences–Biomarkers, Bioinformatics and Omics & Pathology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

  ⨯
• Aaron Baker,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Computer Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Morgridge Institute for Research, Madison, Wisconsin, United States of America

  https://orcid.org/0000-0002-2815-9932

  ⨯
• Sabrina Golling,

  Roles Methodology

  Affiliation Roche Pharma Research and Early Development, Pharmaceutical Sciences–Biomarkers, Bioinformatics and Omics & Pathology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

  ⨯
• Juliane Siebourg Polster,

  Roles Formal analysis

  Affiliation Roche Pharma Research and Early Development, Pharmaceutical Sciences–Biomarkers, Bioinformatics and Omics & Pathology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

  ⨯
• Mitchell P. Ledwith,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – review & editing

  Affiliation Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  ⨯
• Anthony Gitter,

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Computer Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Morgridge Institute for Research, Madison, Wisconsin, United States of America, Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  https://orcid.org/0000-0002-5324-9833

  ⨯
• Angelique Augustin,

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

  Affiliation Roche Pharma Research and Early Development, Pharmaceutical Sciences–Biomarkers, Bioinformatics and Omics & Pathology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

  ⨯
• Hassan Javanbakht,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Current address: Bluejay Therapeutics, San Francisco, California, United States of America

  Affiliation Roche Pharma Research and Early Development, Infectious Diseases, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

  ⨯
• Andrew Mehle

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: sbaker@lovelacebiomedical.org (SFB); amehle@wisc.edu (AM)

  Affiliation Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  https://orcid.org/0000-0001-6060-4330

  ⨯