The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration

• Mazal Cohen-Gulkar ,

  Contributed equally to this work with: Mazal Cohen-Gulkar, Ahuvit David, Naama Messika-Gold

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv, Israel

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• Ahuvit David ,

  Contributed equally to this work with: Mazal Cohen-Gulkar, Ahuvit David, Naama Messika-Gold

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv, Israel

  ⨯
• Naama Messika-Gold ,

  Contributed equally to this work with: Mazal Cohen-Gulkar, Ahuvit David, Naama Messika-Gold

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv, Israel

  ⨯
• Mai Eshel,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv, Israel

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• Shai Ovadia,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv, Israel

  ⨯
• Nitay Zuk-Bar,

  Roles Formal analysis, Investigation, Methodology, Validation

  Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv, Israel

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• Maria Idelson,

  Roles Methodology, Resources

  Affiliation The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy and Department of Gynecology, Jerusalem, Israel

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• Yamit Cohen-Tayar,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv, Israel

  ⨯
• Benjamin Reubinoff,

  Roles Methodology, Resources

  Affiliation The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy and Department of Gynecology, Jerusalem, Israel

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• Tamar Ziv,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Smoler Proteomics Center, Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering, Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel

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• Meir Shamay,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Daniella Lee Casper Laboratory in Viral Oncology, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel

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• Ran Elkon ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – original draft

  * E-mail: ranel@tauex.tau.ac.il (RE); ruthash@tauex.tau.ac.il (RAP)

  Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv, Israel

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• Ruth Ashery-Padan

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Visualization, Writing – original draft

  * E-mail: ranel@tauex.tau.ac.il (RE); ruthash@tauex.tau.ac.il (RAP)

  Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv, Israel

  https://orcid.org/0000-0002-5364-6898

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