Analysis of the evolution of resistance to multiple antibiotics enables prediction of the Escherichia coli phenotype-based fitness landscape

• Junichiro Iwasawa,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Physics, Graduate School of Science, University of Tokyo, Tokyo, Japan

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• Tomoya Maeda,

  Roles Investigation, Writing – review & editing

  Affiliation Graduate School of Agriculture Research, Faculty of Agriculture, Hokkaido University, Sapporo, Japan

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• Atsushi Shibai,

  Roles Investigation

  Affiliation Center for Biosystems Dynamics Research, RIKEN, Suita, Japan

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• Hazuki Kotani,

  Roles Investigation

  Affiliation Center for Biosystems Dynamics Research, RIKEN, Suita, Japan

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• Masako Kawada,

  Roles Investigation

  Affiliation Center for Biosystems Dynamics Research, RIKEN, Suita, Japan

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• Chikara Furusawa

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: chikara.furusawa@riken.jp

  Affiliations Department of Physics, Graduate School of Science, University of Tokyo, Tokyo, Japan, Center for Biosystems Dynamics Research, RIKEN, Suita, Japan, Universal Biology Institute, Graduate School of Science, University of Tokyo, Tokyo, Japan

  https://orcid.org/0000-0003-3554-4975

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