Hypermutator strains of Pseudomonas aeruginosa reveal novel pathways of resistance to combinations of cephalosporin antibiotics and beta-lactamase inhibitors

• Augusto Dulanto Chiang ,

  Contributed equally to this work with: Augusto Dulanto Chiang, Prashant P. Patil

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Bacterial Pathogenesis and Antimicrobial Resistance Unit, LCIM, NIAID, NIH, Bethesda, Maryland, United States of America

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• Prashant P. Patil ,

  Contributed equally to this work with: Augusto Dulanto Chiang, Prashant P. Patil

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Bacterial Pathogenesis and Antimicrobial Resistance Unit, LCIM, NIAID, NIH, Bethesda, Maryland, United States of America

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• Lidia Beka,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: National Cancer Institute, NIH, Bethesda, Maryland, United States of America

  Affiliation Bacterial Pathogenesis and Antimicrobial Resistance Unit, LCIM, NIAID, NIH, Bethesda, Maryland, United States of America

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• Jung-Ho Youn,

  Roles Data curation, Investigation, Methodology

  Affiliation Dept. Laboratory Medicine, NIH Clinical Center, NIH, Bethesda, Maryland, United States of America

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• Adrien Launay,

  Roles Investigation, Methodology, Software, Writing – review & editing

  Affiliation Bacterial Pathogenesis and Antimicrobial Resistance Unit, LCIM, NIAID, NIH, Bethesda, Maryland, United States of America

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• Robert A. Bonomo,

  Roles Conceptualization, Writing – review & editing

  Affiliations Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, United States of America, Departments of Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES) Cleveland, Ohio, United States of America

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• Pavel P. Khil,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Bacterial Pathogenesis and Antimicrobial Resistance Unit, LCIM, NIAID, NIH, Bethesda, Maryland, United States of America, Dept. Laboratory Medicine, NIH Clinical Center, NIH, Bethesda, Maryland, United States of America

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• John P. Dekker

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: john.dekker@nih.gov

  Affiliations Bacterial Pathogenesis and Antimicrobial Resistance Unit, LCIM, NIAID, NIH, Bethesda, Maryland, United States of America, Dept. Laboratory Medicine, NIH Clinical Center, NIH, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0002-3701-5228

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