APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer’s disease and related dementia

• Chloé Savignac,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada

  https://orcid.org/0000-0002-7730-8324

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• Sylvia Villeneuve,

  Roles Writing – original draft, Writing – review & editing

  Affiliations Department of Neurology and Neurosurgery, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, Quebec, Canada, McConnell Brain Imaging Centre (BIC), MNI, Faculty of Medicine, McGill University, Montreal, Quebec, Canada, Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada, Centre for Studies in the Prevention of Alzheimer’s Disease, Douglas Mental Health Institute, McGill University, Montreal, Quebec, Canada

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• AmanPreet Badhwar,

  Roles Writing – original draft, Writing – review & editing

  Affiliations Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada, Centre de recherche de l’Institut universitaire de gériatrie de Montréal (CRIUGM), Montreal, Quebec, Canada

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• Karin Saltoun,

  Roles Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada

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• Kimia Shafighi,

  Roles Data curation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada

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• Chris Zajner,

  Roles Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada

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• Vaibhav Sharma,

  Roles Data curation, Formal analysis, Software, Writing – review & editing

  Affiliation Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada

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• Sarah A. Gagliano Taliun,

  Roles Writing – original draft, Writing – review & editing

  Affiliations Department of Neurosciences & Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada, Montreal Heart Institute, Montréal, Quebec, Canada

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• Sali Farhan,

  Roles Writing – original draft, Writing – review & editing

  Affiliations Department of Neurology and Neurosurgery, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, Quebec, Canada, Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada

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• Judes Poirier,

  Roles Writing – original draft, Writing – review & editing

  Affiliations Department of Neurology and Neurosurgery, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, Quebec, Canada, Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada, Centre for Studies in the Prevention of Alzheimer’s Disease, Douglas Mental Health Institute, McGill University, Montreal, Quebec, Canada

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• Danilo Bzdok

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: danilo.bzdok@mcgill.ca

  Affiliations Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada, McConnell Brain Imaging Centre (BIC), MNI, Faculty of Medicine, McGill University, Montreal, Quebec, Canada, School of Computer Science, McGill University, Montreal, Quebec, Canada, Mila—Quebec Artificial Intelligence Institute, Montreal, Quebec, Canada

  https://orcid.org/0000-0003-3466-6620

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