Global genome decompaction leads to stochastic activation of gene expression as a first step toward fate commitment in human hematopoietic cells

• Romuald Parmentier ,

  Contributed equally to this work with: Romuald Parmentier, Laëtitia Racine, Alice Moussy, Sophie Chantalat

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft

  Affiliation École Pratique des Hautes Études, PSL Research University, St-Antoine Research Center, Inserm U938, AP-HP, SIRIC CURAMUS, Paris, France

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• Laëtitia Racine ,

  Contributed equally to this work with: Romuald Parmentier, Laëtitia Racine, Alice Moussy, Sophie Chantalat

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation École Pratique des Hautes Études, PSL Research University, St-Antoine Research Center, Inserm U938, AP-HP, SIRIC CURAMUS, Paris, France

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• Alice Moussy ,

  Contributed equally to this work with: Romuald Parmentier, Laëtitia Racine, Alice Moussy, Sophie Chantalat

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation École Pratique des Hautes Études, PSL Research University, St-Antoine Research Center, Inserm U938, AP-HP, SIRIC CURAMUS, Paris, France

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• Sophie Chantalat ,

  Contributed equally to this work with: Romuald Parmentier, Laëtitia Racine, Alice Moussy, Sophie Chantalat

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization

  Affiliation Centre National de Recherche en Génomique Humaine, Evry, France

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• Ravi Sudharshan,

  Roles Data curation, Formal analysis, Software, Visualization

  Affiliations Department of Chemical and Biological Engineering, University, Buffalo, New York, United States of America, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland

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• Nan Papili Gao,

  Roles Data curation, Formal analysis, Investigation, Software

  Affiliation Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland

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• Daniel Stockholm,

  Roles Data curation, Formal analysis

  Affiliation École Pratique des Hautes Études, PSL Research University, St-Antoine Research Center, Inserm U938, AP-HP, SIRIC CURAMUS, Paris, France

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• Guillaume Corre,

  Roles Data curation, Formal analysis, Software

  Affiliation Genethon, Evry, France

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• Geneviève Fourel,

  Roles Formal analysis, Visualization, Writing – original draft

  Affiliations Laboratory of Biology and Modelling of the Cell, University of Lyon, ENS de Lyon, University of Claude Bernard, CNRS UMR 5239, Inserm U1210, Lyon, France, Centre Blaise Pascal, ENS de Lyon, Lyon, France

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• Jean-François Deleuze,

  Roles Funding acquisition, Supervision, Validation

  Affiliation Centre National de Recherche en Génomique Humaine, Evry, France

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• Rudiyanto Gunawan,

  Roles Formal analysis, Investigation, Software, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemical and Biological Engineering, University, Buffalo, New York, United States of America

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• Andras Paldi

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: andras.paldi@ephe.psl.eu

  Affiliation École Pratique des Hautes Études, PSL Research University, St-Antoine Research Center, Inserm U938, AP-HP, SIRIC CURAMUS, Paris, France

  https://orcid.org/0000-0003-4446-7625

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