Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination

• Valerie A. C. M. Koeken,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliations Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands, Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany, TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany

  https://orcid.org/0000-0002-5783-9013

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• Cancan Qi,

  Roles Formal analysis, Visualization, Writing – original draft

  Affiliations Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany, TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany

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• Vera P. Mourits,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands

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• L. Charlotte J. de Bree,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands

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• Simone J. C. F. M. Moorlag,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands

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• Vidhisha Sonawane,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands

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• Heidi Lemmers,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands

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• Helga Dijkstra,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands

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• Leo A. B. Joosten,

  Roles Supervision, Writing – review & editing

  Affiliations Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands, Department of Medical Genetics, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

  https://orcid.org/0000-0001-6166-9830

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• Arjan van Laarhoven,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands

  https://orcid.org/0000-0002-6607-4075

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• Cheng-Jian Xu,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliations Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands, Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany, TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany

  https://orcid.org/0000-0003-1586-4672

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• Reinout van Crevel,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands

  https://orcid.org/0000-0002-6233-6410

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• Mihai G. Netea ,

  Contributed equally to this work with: Mihai G. Netea, Yang Li

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliations Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands, Department of Medical Genetics, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, Department for Immunology and Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany

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• Yang Li

  Contributed equally to this work with: Mihai G. Netea, Yang Li

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: Yang.Li@helmholtz-hzi.de

  Affiliations Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands, Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany, TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany

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