Primary and metastatic tumors exhibit systems-level differences in dependence on mitochondrial respiratory function

• Neal K. Bennett ,

  Contributed equally to this work with: Neal K. Bennett, Hiroki J. Nakaoka

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliation Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, United States of America

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• Hiroki J. Nakaoka ,

  Contributed equally to this work with: Neal K. Bennett, Hiroki J. Nakaoka

  Roles Data curation, Formal analysis, Investigation

  Affiliation Department of Radiation Oncology, University of California, San Francisco, San Francisco, California, United States of America

  ⨯
• Danny Laurent,

  Roles Formal analysis

  Affiliation Department of Radiation Oncology, University of California, San Francisco, San Francisco, California, United States of America

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• Ross A. Okimoto,

  Roles Investigation, Methodology

  Affiliation Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America

  https://orcid.org/0000-0002-4467-8476

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• Yoshitaka Sei,

  Roles Formal analysis, Methodology

  Affiliation Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, United States of America

  ⨯
• Andrew E. Horvai,

  Roles Formal analysis

  Affiliation Department of Pathology, University of California, San Francisco, San Francisco, California, United States of America

  ⨯
• Trever G. Bivona,

  Roles Methodology, Resources

  Affiliation Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America

  ⨯
• Johanna ten Hoeve,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft

  Affiliation Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, UCLA Metabolomics Center, University of California, Los Angeles, Los Angeles, California, United States of America

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• Thomas G. Graeber,

  Roles Formal analysis, Methodology, Supervision, Writing – original draft

  Affiliation Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, UCLA Metabolomics Center, University of California, Los Angeles, Los Angeles, California, United States of America

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• Ken Nakamura,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft

  Affiliations Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, United States of America, Graduate Programs in Neuroscience and Biomedical Sciences, University of California, San Francisco, San Francisco, California, United States of America, Department of Neurology, University of California, San Francisco, San Francisco, California, United States of America

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• Jean L. Nakamura

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Jean.Nakamura@ucsf.edu

  Affiliation Department of Radiation Oncology, University of California, San Francisco, San Francisco, California, United States of America

  https://orcid.org/0000-0002-2097-9223

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