Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface

• Yunseok Heo ,

  Contributed equally to this work with: Yunseok Heo, Naito Ishimoto

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Structural Biochemistry & Molecular Biophysics Laboratory, Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea, Research Center for Bioconvergence Analysis, Korea Basic Science Institute (KBSI), Chungbuk, Korea

  https://orcid.org/0000-0002-2233-4306

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• Naito Ishimoto ,

  Contributed equally to this work with: Yunseok Heo, Naito Ishimoto

  Roles Data curation, Formal analysis, Validation, Visualization, Writing – review & editing

  Affiliation Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi, Yokohama, Japan

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• Ye-Eun Jeon,

  Roles Data curation, Formal analysis, Validation

  Affiliation Structural Biochemistry & Molecular Biophysics Laboratory, Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea

  ⨯
• Ji-Hye Yun,

  Roles Conceptualization, Methodology, Validation

  Affiliations Structural Biochemistry & Molecular Biophysics Laboratory, Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea, PCG-Biotech, Ltd., Seoul, Korea

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• Mio Ohki,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi, Yokohama, Japan

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• Yuki Anraku,

  Roles Data curation, Formal analysis

  Affiliation Faculty of Pharmaceutical Sciences and Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Hokkaido, Japan

  ⨯
• Mina Sasaki,

  Roles Data curation, Formal analysis

  Affiliation Faculty of Pharmaceutical Sciences and Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Hokkaido, Japan

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• Shunsuke Kita,

  Roles Data curation, Formal analysis

  Affiliation Faculty of Pharmaceutical Sciences and Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Hokkaido, Japan

  ⨯
• Hideo Fukuhara,

  Roles Data curation, Formal analysis

  Affiliation Faculty of Pharmaceutical Sciences and Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Hokkaido, Japan

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• Tatsuya Ikuta,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

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• Kouki Kawakami,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

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• Asuka Inoue,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

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• Katsumi Maenaka,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Faculty of Pharmaceutical Sciences and Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Hokkaido, Japan

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• Jeremy R. H. Tame,

  Roles Validation, Writing – original draft, Writing – review & editing

  Affiliation Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi, Yokohama, Japan

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• Weontae Lee ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: wtlee@yonsei.ac.kr (WL); park@yokohama-cu.ac.jp (S-YP)

  Affiliations Structural Biochemistry & Molecular Biophysics Laboratory, Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea, PCG-Biotech, Ltd., Seoul, Korea

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•  [ ... ],
• Sam-Yong Park

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: wtlee@yonsei.ac.kr (WL); park@yokohama-cu.ac.jp (S-YP)

  Affiliation Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi, Yokohama, Japan

  https://orcid.org/0000-0001-6164-8896

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