If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?

• Christian Haass ,

  * E-mail: Christian.Haass@dzne.de (CH); dselkoe@bwh.harvard.edu (DS)

  Affiliations German Center for Neurodegenerative Diseases (DZNE), Munich, Germany, Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians University, Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

  https://orcid.org/0000-0002-4869-1627

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• Dennis Selkoe

  * E-mail: Christian.Haass@dzne.de (CH); dselkoe@bwh.harvard.edu (DS)

  Affiliation Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-8846-9767

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