Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia

Madeline R. Scott; Wei Zong; Kyle D. Ketchesin; Marianne L. Seney; George C. Tseng; Bokai Zhu; Colleen A. McClung

doi:10.1371/journal.pbio.3001688

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Open Access

Peer-reviewed

Research Article

Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia

Madeline R. Scott,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft

Affiliation Translational Neuroscience Program, Department of Psychiatry, Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Wei Zong,

Roles Data curation, Formal analysis, Methodology, Visualization, Writing – review & editing

Affiliation Department of Bioinformatics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Kyle D. Ketchesin,

Roles Validation, Writing – review & editing

Affiliation Translational Neuroscience Program, Department of Psychiatry, Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Marianne L. Seney,

Roles Validation, Writing – review & editing

Affiliation Translational Neuroscience Program, Department of Psychiatry, Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
George C. Tseng,

Roles Methodology, Supervision, Writing – review & editing

Affiliation Department of Bioinformatics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Bokai Zhu ,

Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

* E-mail: bzhu@pitt.edu (BZ); mcclungca@upmc.edu (CAM)

Affiliation Aging Institute of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

https://orcid.org/0000-0003-0827-5757

⨯
Colleen A. McClung

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: bzhu@pitt.edu (BZ); mcclungca@upmc.edu (CAM)

Affiliation Translational Neuroscience Program, Department of Psychiatry, Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia

Madeline R. Scott,
Wei Zong,
Kyle D. Ketchesin,
Marianne L. Seney,
George C. Tseng,
Bokai Zhu,
Colleen A. McClung

Published: January 24, 2023
https://doi.org/10.1371/journal.pbio.3001688

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Schizophrenia
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Prefrontal cortex
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Circadian rhythms
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