Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent-like state

• Yang Yang ,

  Contributed equally to this work with: Yang Yang, Liyang Shi

  Roles Data curation, Investigation

  Affiliation Center for Reproductive Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

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• Liyang Shi ,

  Contributed equally to this work with: Yang Yang, Liyang Shi

  Roles Formal analysis, Software

  Affiliation Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

  ⨯
• Xiuling Fu,

  Roles Data curation, Formal analysis

  Affiliation Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

  ⨯
• Gang Ma,

  Roles Formal analysis, Investigation

  Affiliation Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

  https://orcid.org/0000-0002-8302-124X

  ⨯
• Zhongzhou Yang,

  Roles Formal analysis

  Affiliation BGI Genomics, BGI-Shenzhen, Shenzhen, China

  ⨯
• Yuhao Li,

  Roles Formal analysis, Validation

  Affiliation Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

  ⨯
• Yibin Zhou,

  Roles Formal analysis, Writing – review & editing

  Affiliation Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

  ⨯
• Lihua Yuan,

  Roles Formal analysis

  Affiliation Center for Reproductive Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

  ⨯
• Ye Xia,

  Roles Data curation, Formal analysis, Validation

  Affiliation Center for Reproductive Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

  ⨯
• Xiufang Zhong,

  Roles Data curation, Formal analysis, Validation

  Affiliation Center for Reproductive Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

  ⨯
• Ping Yin,

  Roles Formal analysis

  Affiliation Center for Reproductive Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

  ⨯
• Li Sun,

  Roles Formal analysis, Validation

  Affiliation Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

  ⨯
• Wuwen Zhang,

  Roles Formal analysis, Supervision, Validation

  Affiliation Center for Reproductive Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

  ⨯
• Isaac A. Babarinde,

  Roles Formal analysis, Writing – review & editing

  Affiliation Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

  ⨯
• Yongjun Wang,

  Roles Formal analysis, Validation

  Affiliations Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China

  ⨯
• Xiaoyang Zhao,

  Roles Validation, Writing – review & editing

  Affiliations State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China, Guangdong Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou, Guangdong, China, Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou, Guangdong, China

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• Andrew P. Hutchins ,

  Roles Formal analysis, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: andrewh@sustech.edu.cn (APH); drivftongguoqing@shutcm.edu.cn (GT)

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

  https://orcid.org/0000-0001-7784-2255

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•  [ ... ],
• Guoqing Tong

  Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: andrewh@sustech.edu.cn (APH); drivftongguoqing@shutcm.edu.cn (GT)

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Center for Reproductive Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

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