The Aedes aegypti siRNA pathway mediates broad-spectrum defense against human pathogenic viruses and modulates antibacterial and antifungal defenses

• Yuemei Dong ,

  Contributed equally to this work with: Yuemei Dong, Shengzhang Dong

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Shengzhang Dong ,

  Contributed equally to this work with: Yuemei Dong, Shengzhang Dong

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0002-8218-4688

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• Nahid Borhani Dizaji,

  Roles Investigation, Methodology

  Affiliation W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Natalie Rutkowski,

  Roles Investigation, Methodology

  Affiliation W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

  ⨯
• Tyler Pohlenz,

  Roles Investigation, Methodology

  Affiliation Texas A & M University, Department of Entomology, TAMU College Station, Texas, United States of America

  ⨯
• Kevin Myles,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Writing – review & editing

  Affiliation Texas A & M University, Department of Entomology, TAMU College Station, Texas, United States of America

  ⨯
• George Dimopoulos

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: gdimopo1@jhu.edu

  Affiliation W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0001-6755-8111

  ⨯