Adverse effects following anti–COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes

Ayesa Syenina; Esther S. Gan; Justin Z. N. Toh; Ruklanthi de Alwis; Lowell Z. Lin; Christine Y. L. Tham; Jia Xin Yee; Yan Shan Leong; Huizhen Sam; Charlene Cheong; Yii Ean Teh; Ian L. E. Wee; Dorothy H. L. Ng; Kuan Rong Chan; Jean X. Y. Sim; Shirin Kalimuddin; Eugenia Z. Ong; Jenny G. Low; Eng Eong Ooi

doi:10.1371/journal.pbio.3001643

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Peer-reviewed

Research Article

Adverse effects following anti–COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes

Ayesa Syenina ,

Contributed equally to this work with: Ayesa Syenina, Esther S. Gan

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliations Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore

https://orcid.org/0000-0003-0061-8401

⨯
Esther S. Gan ,

Contributed equally to this work with: Ayesa Syenina, Esther S. Gan

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore
⨯
Justin Z. N. Toh,

Roles Investigation

Affiliations Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, School of Life Sciences, Nanyang Polytechnic, Singapore
⨯
Ruklanthi de Alwis,

Roles Data curation, Formal analysis, Funding acquisition, Methodology

Affiliations Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore
⨯
Lowell Z. Lin,

Roles Investigation

Affiliation Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore
⨯
Christine Y. L. Tham,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliations Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore
⨯
Jia Xin Yee,

Roles Investigation, Project administration, Resources

Affiliations Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore
⨯
Yan Shan Leong,

Roles Project administration, Resources

Affiliations Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore
⨯
Huizhen Sam,

Roles Project administration, Resources

Affiliation Department of Infectious Diseases, Singapore General Hospital, Singapore
⨯
Charlene Cheong,

Roles Project administration, Resources

Affiliation Department of Infectious Diseases, Singapore General Hospital, Singapore
⨯
Yii Ean Teh,

Roles Resources

Affiliation Department of Infectious Diseases, Singapore General Hospital, Singapore
⨯
Ian L. E. Wee,

Roles Resources

Affiliation Department of Infectious Diseases, Singapore General Hospital, Singapore
⨯
Dorothy H. L. Ng,

Roles Resources

Affiliation Department of Infectious Diseases, Singapore General Hospital, Singapore
⨯
Kuan Rong Chan,

Roles Methodology

Affiliation Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore
⨯
Jean X. Y. Sim,

Roles Resources

Affiliation Department of Infectious Diseases, Singapore General Hospital, Singapore
⨯
Shirin Kalimuddin,

Roles Resources

Affiliations Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Department of Infectious Diseases, Singapore General Hospital, Singapore
⨯
Eugenia Z. Ong,

Roles Methodology, Project administration, Validation

Affiliations Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore
⨯
Jenny G. Low,

Roles Resources, Supervision

Affiliations Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Department of Infectious Diseases, Singapore General Hospital, Singapore
⨯
[ ... ],
Eng Eong Ooi

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: engeong.ooi@duke-nus.edu.sg

Affiliations Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Department of Infectious Diseases, Singapore General Hospital, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore

https://orcid.org/0000-0002-0520-1544

⨯
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Adverse effects following anti–COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes

Ayesa Syenina,
Esther S. Gan,
Justin Z. N. Toh,
Ruklanthi de Alwis,
Lowell Z. Lin,
Christine Y. L. Tham,
Jia Xin Yee,
Yan Shan Leong,
Huizhen Sam,
Charlene Cheong

Published: May 31, 2022
https://doi.org/10.1371/journal.pbio.3001643

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13 Nov 2022
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