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A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models
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Dharaminder Singh ,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing
* E-mail: Dharaminder.Singh@CN-Bio.com
Affiliation CN Bio Innovations Limited, Cambridge, United Kingdom
⨯ - Sudhir P. Deosarkar,
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Elaine Cadogan,
Roles Formal analysis, Methodology, Writing – review & editing
Affiliation Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom
⨯ - Vikki Flemington,
- Alysha Bray,
- Jingwen Zhang,
- Ronald S. Reiserer,
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David K. Schaffer,
Roles Conceptualization, Methodology, Software
Affiliation Department of Physics and Astronomy and the Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, Tennessee, United States of America
⨯ - Gregory B. Gerken,
- Clayton M. Britt,
- Erik M. Werner,
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Francis D. Gibbons,
Roles Conceptualization, Formal analysis, Methodology
Affiliation DMPK, Oncology R&D, AstraZeneca, Boston, Massachusetts, United States of America
⨯ -
Tomasz Kostrzewski,
Roles Conceptualization, Formal analysis, Writing – review & editing
Affiliation CN Bio Innovations Limited, Cambridge, United Kingdom
⨯ - Christopher E. Chambers,
- Emma J. Davies,
- Antonio Ramos Montoya,
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Jacqueline H. L. Fok,
Roles Conceptualization, Investigation, Methodology
Affiliation Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom
⨯ - David Hughes,
- Kristin Fabre,
- Matthew P. Wagoner,
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John P. Wikswo,
Roles Conceptualization, Methodology, Software, Writing – review & editing
Affiliations Department of Physics and Astronomy and the Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, Tennessee, United States of America, Departments of Biomedical Engineering and Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America
⨯ - [ ... ],
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Clay W. Scott
Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing
Affiliation Oncology Safety, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts, United States of America
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https://orcid.org/0000-0003-4630-6403
A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models
- Dharaminder Singh,
- Sudhir P. Deosarkar,
- Elaine Cadogan,
- Vikki Flemington,
- Alysha Bray,
- Jingwen Zhang,
- Ronald S. Reiserer,
- David K. Schaffer,
- Gregory B. Gerken,
- Clayton M. Britt
- Published: May 26, 2022
- https://doi.org/10.1371/journal.pbio.3001624