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Open Access
Peer-reviewed
Meta-Research Article
Meta-Research Articles feature data-driven examinations of the methods, reporting, verification, and evaluation of scientific research.
Systematically assessing microbiome–disease associations identifies drivers of inconsistency in metagenomic research
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Braden T. Tierney,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America, Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, Massachusetts, United States of America, Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
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Yingxuan Tan,
Roles Data curation, Formal analysis, Investigation, Software
Current address: Department of Computer Science, Stanford University, Stanford California, United States of America
Affiliation Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America
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Zhen Yang,
Roles Data curation, Investigation
Affiliations Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, Massachusetts, United States of America, Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
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Bing Shui,
Roles Data curation, Investigation
Affiliation Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
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Michaela J. Walker,
Roles Data curation, Investigation
Affiliation UPSIDE Foods, Berkeley, California, United States of America
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Benjamin M. Kent,
Roles Data curation, Investigation
Affiliation US Marine Corps, Camp Pendleton, California, United States of America
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Aleksandar D. Kostic ,
Roles Conceptualization, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: Aleksandar.Kostic@joslin.harvard.edu (ADK); chirag_patel@hms.harvard.edu (CJP)
Affiliations Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, Massachusetts, United States of America, Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
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Chirag J. Patel
Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: Aleksandar.Kostic@joslin.harvard.edu (ADK); chirag_patel@hms.harvard.edu (CJP)
Affiliation Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America
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Systematically assessing microbiome–disease associations identifies drivers of inconsistency in metagenomic research
- Braden T. Tierney,
- Yingxuan Tan,
- Zhen Yang,
- Bing Shui,
- Michaela J. Walker,
- Benjamin M. Kent,
- Aleksandar D. Kostic,
- Chirag J. Patel
- Published: March 2, 2022
- https://doi.org/10.1371/journal.pbio.3001556