Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing

• Guadalupe J. Jasso ,

  Contributed equally to this work with: Guadalupe J. Jasso, Alok Jaiswal

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Alok Jaiswal ,

  Contributed equally to this work with: Guadalupe J. Jasso, Alok Jaiswal

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0002-1910-4681

  ⨯
• Mukund Varma,

  Roles Formal analysis

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0002-9254-1247

  ⨯
• Tyler Laszewski,

  Roles Investigation

  Affiliation Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

  ⨯
• Angelo Grauel,

  Roles Investigation

  Affiliation Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

  ⨯
• Abdifatah Omar,

  Roles Investigation

  Affiliation Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-2682-8127

  ⨯
• Nilsa Silva,

  Roles Investigation

  Affiliation Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

  ⨯
• Glenn Dranoff,

  Roles Resources

  Affiliation Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

  ⨯
• Jeffrey A. Porter,

  Roles Resources

  Affiliation Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

  ⨯
• Keith Mansfield,

  Roles Resources

  Affiliation Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

  ⨯
• Viviana Cremasco,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

  ⨯
• Aviv Regev,

  Roles Resources

  Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute and David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Ramnik J. Xavier ,

  Roles Conceptualization, Funding acquisition, Supervision

  * E-mail: xavier@molbio.mgh.harvard.edu (RJX); dgraham@broadinstitute.org (DBG)

  Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0002-5630-5167

  ⨯
• Daniel B. Graham

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: xavier@molbio.mgh.harvard.edu (RJX); dgraham@broadinstitute.org (DBG)

  ¶‡ Lead contact.

  Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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