Macrophages take up VLDL-sized emulsion particles through caveolae-mediated endocytosis and excrete part of the internalized triglycerides as fatty acids

Lei Deng; Frank Vrieling; Rinke Stienstra; Guido J. Hooiveld; Anouk L. Feitsma; Sander Kersten

doi:10.1371/journal.pbio.3001516

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Peer-reviewed

Research Article

Macrophages take up VLDL-sized emulsion particles through caveolae-mediated endocytosis and excrete part of the internalized triglycerides as fatty acids

Lei Deng,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands

https://orcid.org/0000-0002-7786-9738

⨯
Frank Vrieling,

Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

Affiliation Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands
⨯
Rinke Stienstra,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands, Department of Internal Medicine, RadboudUMC, Nijmegen, the Netherlands
⨯
Guido J. Hooiveld,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands
⨯
Anouk L. Feitsma,

Roles Conceptualization, Investigation, Supervision, Writing – review & editing

Affiliation FrieslandCampina, Amersfoort, the Netherlands
⨯
Sander Kersten

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: sander.kersten@wur.nl

Affiliation Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands
⨯

Macrophages take up VLDL-sized emulsion particles through caveolae-mediated endocytosis and excrete part of the internalized triglycerides as fatty acids

Lei Deng,
Frank Vrieling,
Rinke Stienstra,
Guido J. Hooiveld,
Anouk L. Feitsma,
Sander Kersten

Published: August 26, 2022
https://doi.org/10.1371/journal.pbio.3001516

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Macrophages
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Emulsions
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Lipids
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Lysosomes
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Fatty acids
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Fluorescence imaging
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Endocytosis
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Lipoproteins
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