Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia

• Adamantios Mamais,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliations Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America, Department of Neurology, University of Florida, Gainesville, Florida, United States of America

  https://orcid.org/0000-0002-5546-7084

  ⨯
• Jillian H. Kluss,

  Roles Formal analysis, Investigation

  Affiliation Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America

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• Luis Bonet-Ponce,

  Roles Data curation, Formal analysis

  Affiliation Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America

  https://orcid.org/0000-0001-9276-059X

  ⨯
• Natalie Landeck,

  Roles Formal analysis, Investigation

  Affiliation Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America

  https://orcid.org/0000-0002-8399-4009

  ⨯
• Rebekah G. Langston,

  Roles Formal analysis, Investigation

  Affiliation Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America

  https://orcid.org/0000-0003-0123-7934

  ⨯
• Nathan Smith,

  Roles Data curation, Formal analysis

  Affiliation Department of Biochemistry and the Redox Biology Center, University of Nebraska, Lincoln, Nebraska, United States of America

  ⨯
• Alexandra Beilina,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America

  ⨯
• Alice Kaganovich,

  Roles Data curation, Formal analysis

  Affiliation Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America

  https://orcid.org/0000-0003-2981-1731

  ⨯
• Manik C. Ghosh,

  Roles Data curation, Formal analysis

  Affiliation Molecular Medicine Branch, ‘Eunice Kennedy Shriver’ National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America

  ⨯
• Laura Pellegrini,

  Roles Formal analysis, Investigation

  Affiliation MRC Laboratory of Molecular Biology, Cambridge, United Kingdom

  https://orcid.org/0000-0002-8814-664X

  ⨯
• Ravindran Kumaran,

  Roles Conceptualization, Formal analysis

  Affiliation Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America

  ⨯
• Ioannis Papazoglou,

  Roles Formal analysis

  Affiliation National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• George R. Heaton,

  Roles Formal analysis

  Affiliation Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America

  ⨯
• Rina Bandopadhyay,

  Roles Data curation

  Affiliation UCL Institute of Neurology and Reta Lila Weston Institute of Neurological Studies, University College London, London, United Kingdom

  https://orcid.org/0000-0003-3502-8815

  ⨯
• Nunziata Maio,

  Roles Formal analysis, Investigation

  Affiliation Molecular Medicine Branch, ‘Eunice Kennedy Shriver’ National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America

  ⨯
• Changyoun Kim,

  Roles Conceptualization, Investigation, Methodology

  Affiliation Molecular Neuropathology Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Matthew J. LaVoie,

  Roles Resources, Supervision

  Affiliation Department of Neurology, University of Florida, Gainesville, Florida, United States of America

  https://orcid.org/0000-0002-2583-1578

  ⨯
• David C. Gershlick,

  Roles Data curation, Investigation

  Affiliation Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

  https://orcid.org/0000-0002-0602-210X

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•  [ ... ],
• Mark R. Cookson

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: cookson@mail.nih.gov

  Affiliation Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America

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