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A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation
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Christopher E. Smith ,
Contributed equally to this work with: Christopher E. Smith, Yien Che Tsai
Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland, United States of America
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Yien Che Tsai ,
Contributed equally to this work with: Christopher E. Smith, Yien Che Tsai
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: tsaiyien@mail.nih.gov (YCT); weissmaa@mail.nih.gov (AMW)
Affiliation Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland, United States of America
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Yu-He Liang,
Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft
Current Address: RCSB Protein Data Bank, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
Affiliation Center for Structural Biology, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland, United States of America
⨯ - Domarin Khago,
- Jennifer Mariano,
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Jess Li,
Roles Investigation, Resources
Affiliation Center for Structural Biology, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland, United States of America
⨯ - Sergey G. Tarasov,
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Emma Gergel,
Roles Investigation
Affiliation Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland, United States of America
⨯ - Borong Tsai,
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Matthew Villaneuva,
Roles Investigation
Affiliation Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland, United States of America
⨯ - Michelle E. Clapp,
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Valentin Magidson,
Roles Methodology, Supervision, Visualization
Affiliation Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯ - Raj Chari,
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R. Andrew Byrd,
Roles Data curation, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Visualization, Writing – original draft
Affiliation Center for Structural Biology, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland, United States of America
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Xinhua Ji,
Roles Data curation, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Visualization, Writing – original draft
Affiliation Center for Structural Biology, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland, United States of America
⨯ - [ ... ],
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Allan M. Weissman
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: tsaiyien@mail.nih.gov (YCT); weissmaa@mail.nih.gov (AMW)
Affiliation Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland, United States of America
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https://orcid.org/0000-0003-0820-0341
A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation
- Christopher E. Smith,
- Yien Che Tsai,
- Yu-He Liang,
- Domarin Khago,
- Jennifer Mariano,
- Jess Li,
- Sergey G. Tarasov,
- Emma Gergel,
- Borong Tsai,
- Matthew Villaneuva
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- Published: December 8, 2021
- https://doi.org/10.1371/journal.pbio.3001474