Cysteine and iron accelerate the formation of ribose-5-phosphate, providing insights into the evolutionary origins of the metabolic network structure

• Gabriel Piedrafita,

  Roles Conceptualization, Methodology, Validation, Visualization, Writing – review & editing

  Current address: Spanish National Cancer Research Center (CNIO), Madrid, Spain

  Affiliation Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, United Kingdom

  https://orcid.org/0000-0001-8701-1084

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• Sreejith J. Varma,

  Roles Investigation, Methodology

  Affiliation Department of Biochemistry, Charité Universitätsmedizin Berlin, Berlin, Germany

  https://orcid.org/0000-0002-1669-2254

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• Cecilia Castro,

  Roles Investigation, Methodology

  Affiliation Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, United Kingdom

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• Christoph B. Messner,

  Roles Investigation, Methodology

  Affiliation The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, United Kingdom

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• Lukasz Szyrwiel,

  Roles Investigation

  Affiliations Department of Biochemistry, Charité Universitätsmedizin Berlin, Berlin, Germany, The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, United Kingdom

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• Julian L. Griffin,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, United Kingdom, The Rowett Institute, The University of Aberdeen, Aberdeen, United Kingdom

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• Markus Ralser

  Roles Conceptualization, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: markus.ralser@charite.de

  Affiliations Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, United Kingdom, Department of Biochemistry, Charité Universitätsmedizin Berlin, Berlin, Germany, The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, United Kingdom

  https://orcid.org/0000-0001-9535-7413

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