Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism

• Xi Peng ,

  Contributed equally to this work with: Xi Peng, Nan Wang, Angqi Zhu, Hanwen Xu, Jialu Li

  Roles Investigation

  Affiliation Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China

  ⨯
• Nan Wang ,

  Contributed equally to this work with: Xi Peng, Nan Wang, Angqi Zhu, Hanwen Xu, Jialu Li

  Roles Data curation, Formal analysis, Investigation, Visualization

  Affiliation State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China

  https://orcid.org/0000-0001-6840-5336

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• Angqi Zhu ,

  Contributed equally to this work with: Xi Peng, Nan Wang, Angqi Zhu, Hanwen Xu, Jialu Li

  Roles Data curation, Investigation, Software, Visualization

  Affiliation State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China

  ⨯
• Hanwen Xu ,

  Contributed equally to this work with: Xi Peng, Nan Wang, Angqi Zhu, Hanwen Xu, Jialu Li

  Roles Investigation

  Affiliation State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China

  https://orcid.org/0000-0003-0361-6647

  ⨯
• Jialu Li ,

  Contributed equally to this work with: Xi Peng, Nan Wang, Angqi Zhu, Hanwen Xu, Jialu Li

  Roles Data curation, Formal analysis, Investigation, Visualization

  Affiliation Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China

  ⨯
• Yanxia Zhou,

  Roles Investigation

  Affiliation Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China

  ⨯
• Chen Wang,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China

  ⨯
• Qingjie Xiao,

  Roles Data curation, Investigation

  Affiliation Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China

  ⨯
• Li Guo,

  Roles Investigation

  Affiliation Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China

  ⨯
• Fei Liu,

  Roles Data curation, Investigation

  Affiliations Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China, West China School of Pharmacy, Sichuan University, Chengdu, China

  ⨯
• Zhi-jun Jia,

  Roles Methodology

  Affiliations Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China, West China School of Pharmacy, Sichuan University, Chengdu, China

  ⨯
• Huaichuan Duan,

  Roles Data curation, Investigation, Software

  Affiliation School of Pharmacy, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, China

  ⨯
• Jianping Hu,

  Roles Methodology, Software

  Affiliation School of Pharmacy, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, China

  ⨯
• Weidan Yuan,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China, Department of Laboratory Medicine, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, China

  ⨯
• Jia Geng,

  Roles Methodology

  Affiliations Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China, Department of Laboratory Medicine, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, China

  ⨯
• Chuangye Yan ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Software, Supervision, Validation

  * E-mail: yancy2019@mail.tsinghua.edu.cn (CY); xin.jiang@unsw.edu.au (XJ); dengd@scu.edu.cn (DD)

  Affiliation State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China

  ⨯
• Xin Jiang ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: yancy2019@mail.tsinghua.edu.cn (CY); xin.jiang@unsw.edu.au (XJ); dengd@scu.edu.cn (DD)

  Affiliation School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia

  ⨯
•  [ ... ],
• Dong Deng

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: yancy2019@mail.tsinghua.edu.cn (CY); xin.jiang@unsw.edu.au (XJ); dengd@scu.edu.cn (DD)

  Affiliation Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China

  https://orcid.org/0000-0002-8590-9525

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