Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport

Chih-Chia Su; Philip A. Klenotic; Meng Cui; Meinan Lyu; Christopher E. Morgan; Edward W. Yu

doi:10.1371/journal.pbio.3001370

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Open Access

Peer-reviewed

Research Article

Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport

Chih-Chia Su ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization

* E-mail: cxs670@case.edu (C-CS); edward.w.yu@case.edu (EWY)

Affiliation Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

https://orcid.org/0000-0003-3646-327X

⨯
Philip A. Klenotic,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

https://orcid.org/0000-0001-8429-0145

⨯
Meng Cui,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Department of Pharmaceutical Sciences, Northeastern University School of Pharmacy, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-3895-135X

⨯
Meinan Lyu,

Roles Investigation, Methodology

Affiliation Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Christopher E. Morgan,

Roles Investigation, Methodology

Affiliation Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Edward W. Yu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: cxs670@case.edu (C-CS); edward.w.yu@case.edu (EWY)

Affiliation Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

https://orcid.org/0000-0001-5912-1227

⨯

Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport

Chih-Chia Su,
Philip A. Klenotic,
Meng Cui,
Meinan Lyu,
Christopher E. Morgan,
Edward W. Yu

Published: August 12, 2021
https://doi.org/10.1371/journal.pbio.3001370

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Electron cryo-microscopy
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Lipids
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Membrane proteins
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Mycobacterium tuberculosis
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Fungal structure
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Molecular dynamics
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Trehalose
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Crystal structure
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