A conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation

• Weichao Zhang,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0002-0835-890X

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• Xi Yang,

  Roles Formal analysis, Investigation, Validation

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0003-2741-2294

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• Liang Chen,

  Roles Investigation, Methodology

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0002-7186-7109

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• Yun-Yu Liu,

  Roles Investigation, Validation

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0001-6988-9985

  ⨯
• Varsha Venkatarangan,

  Roles Investigation

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Lucas Reist,

  Roles Investigation

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0002-3990-5582

  ⨯
• Phyllis Hanson,

  Roles Resources

  Affiliation Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Haoxing Xu,

  Roles Resources

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0003-3561-4654

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• Yanzhuang Wang,

  Roles Resources

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Ming Li

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: mlium@umich.edu

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0002-1247-2377

  ⨯