Synthesis of human amyloid restricted to liver results in an Alzheimer disease–like neurodegenerative phenotype

• Virginie Lam ,

  Contributed equally to this work with: Virginie Lam, Ryusuke Takechi, John C. L. Mamo

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, Australia, School of Population Health, Faculty of Health Sciences, Curtin University, Bentley, Australia

  https://orcid.org/0000-0001-8463-645X

  ⨯
• Ryusuke Takechi ,

  Contributed equally to this work with: Virginie Lam, Ryusuke Takechi, John C. L. Mamo

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, Australia, School of Population Health, Faculty of Health Sciences, Curtin University, Bentley, Australia

  https://orcid.org/0000-0001-6359-3382

  ⨯
• Mark J. Hackett,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, Australia, School of Molecular and Life Sciences, Faculty of Science and Engineering, Curtin University, Bentley, Australia

  ⨯
• Roslyn Francis,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Department of Nuclear Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia, School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia

  ⨯
• Michael Bynevelt,

  Roles Formal analysis, Methodology, Visualization, Writing – review & editing

  Affiliation Sir Charles Gairdner Hospital, Nedlands, Australia

  ⨯
• Liesl M. Celliers,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Department of Nuclear Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia, Department of Molecular Imaging and Therapy Service, Fiona Stanley Hospital, Murdoch, Australia

  ⨯
• Michael Nesbit,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, Australia, School of Population Health, Faculty of Health Sciences, Curtin University, Bentley, Australia

  ⨯
• Somayra Mamsa,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, Australia

  https://orcid.org/0000-0002-9806-8059

  ⨯
• Frank Arfuso,

  Roles Data curation, Formal analysis, Visualization, Writing – review & editing

  Affiliation Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, Australia

  https://orcid.org/0000-0001-7678-9472

  ⨯
• Sukanya Das,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, Australia

  ⨯
• Frank Koentgen,

  Roles Data curation, Methodology, Resources, Validation, Writing – review & editing

  Affiliation Ozgene Pty Ltd, Bentley, Western Australia, Australia

  https://orcid.org/0000-0002-5660-4028

  ⨯
• Maree Hagan,

  Roles Data curation, Methodology, Resources, Validation, Writing – review & editing

  Affiliation Ozgene Pty Ltd, Bentley, Western Australia, Australia

  https://orcid.org/0000-0003-2379-3552

  ⨯
• Lincoln Codd,

  Roles Data curation, Formal analysis, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Radiology, Sir Charles Gairdner Hospital, Nedlands, Australia

  ⨯
• Kirsty Richardson,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research, University of Western Australia, Centre for Medical Research, QEII Medical Centre, Australia

  ⨯
• Brenton O’Mara,

  Roles Data curation, Formal analysis, Visualization, Writing – review & editing

  Affiliation Department of Nuclear Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia

  ⨯
• Rainer K. Scharli,

  Roles Formal analysis, Methodology, Visualization, Writing – review & editing

  Affiliations Radiopharmaceutical Production and Development Centre (RAPID) PET Laboratories, Sir Charles Gairdner Hospital, Nedlands, Australia, Physics, University of Western Australia, Nedlands, Australia

  ⨯
• Laurence Morandeau,

  Roles Data curation, Formal analysis, Methodology, Visualization, Writing – review & editing

  Affiliations Radiopharmaceutical Production and Development Centre (RAPID) PET Laboratories, Sir Charles Gairdner Hospital, Nedlands, Australia, Physics, University of Western Australia, Nedlands, Australia

  ⨯
• Jonathan Gauntlett,

  Roles Formal analysis, Investigation

  Affiliation Ozgene Pty Ltd, Bentley, Western Australia, Australia

  https://orcid.org/0000-0002-7144-099X

  ⨯
• Christopher Leatherday,

  Roles Formal analysis, Investigation

  Affiliation Health Technology Management Unit, East Metropolitan Health Service, Perth, Australia

  https://orcid.org/0000-0002-8461-5656

  ⨯
• Jan Boucek,

  Roles Formal analysis, Investigation

  Affiliation Health Technology Management Unit, East Metropolitan Health Service, Perth, Australia

  ⨯
•  [ ... ],
• John C. L. Mamo

  Contributed equally to this work with: Virginie Lam, Ryusuke Takechi, John C. L. Mamo

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: J.Mamo@Curtin.edu.au

  Affiliations Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, Australia, School of Population Health, Faculty of Health Sciences, Curtin University, Bentley, Australia

  https://orcid.org/0000-0002-5741-7849

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