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Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
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Jesse I. Mobbs ,
Contributed equally to this work with: Jesse I. Mobbs, Matthew J. Belousoff
Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliation Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
⨯ -
Matthew J. Belousoff ,
Contributed equally to this work with: Jesse I. Mobbs, Matthew J. Belousoff
Roles Formal analysis, Visualization, Writing – review & editing
Affiliations Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia, ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
⨯ - Kaleeckal G. Harikumar,
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Sarah J. Piper,
Roles Formal analysis, Visualization, Writing – review & editing
Affiliation Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
⨯ -
Xiaomeng Xu,
Roles Investigation, Writing – review & editing
Affiliation Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
⨯ -
Sebastian G. B. Furness,
Roles Formal analysis, Supervision, Writing – review & editing
Affiliation Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
⨯ - Hari Venugopal,
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Arthur Christopoulos,
Roles Conceptualization, Funding acquisition, Writing – review & editing
Affiliation Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
⨯ -
Radostin Danev,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Graduate School of Medicine, University of Tokyo, Tokyo, Japan
⨯ - Denise Wootten ,
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David M. Thal ,
Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: denise.wootten@monash.edu (DW); David.thal@monash.edu (DMT); miller@mayo.edu (LJM); Patrick.sexton@monash.edu (PMS)
Affiliation Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
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Laurence J. Miller ,
Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: denise.wootten@monash.edu (DW); David.thal@monash.edu (DMT); miller@mayo.edu (LJM); Patrick.sexton@monash.edu (PMS)
Affiliation Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona, United States of America
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Patrick M. Sexton
Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: denise.wootten@monash.edu (DW); David.thal@monash.edu (DMT); miller@mayo.edu (LJM); Patrick.sexton@monash.edu (PMS)
Affiliations Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia, ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
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https://orcid.org/0000-0001-6979-1427
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
- Jesse I. Mobbs,
- Matthew J. Belousoff,
- Kaleeckal G. Harikumar,
- Sarah J. Piper,
- Xiaomeng Xu,
- Sebastian G. B. Furness,
- Hari Venugopal,
- Arthur Christopoulos,
- Radostin Danev,
- Denise Wootten
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- Published: June 4, 2021
- https://doi.org/10.1371/journal.pbio.3001295