α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes

• Aysegul Dilsizoglu Senol ,

  Contributed equally to this work with: Aysegul Dilsizoglu Senol, Maura Samarani

  Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Unité de Trafic Membranaire et Pathogénèse, Département de Biologie Cellulaire et de l’Infection, Institut Pasteur, Paris, France

  ⨯
• Maura Samarani ,

  Contributed equally to this work with: Aysegul Dilsizoglu Senol, Maura Samarani

  Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Unité de Trafic Membranaire et Pathogénèse, Département de Biologie Cellulaire et de l’Infection, Institut Pasteur, Paris, France

  https://orcid.org/0000-0002-6376-5524

  ⨯
• Sylvie Syan,

  Roles Data curation

  Affiliation Unité de Trafic Membranaire et Pathogénèse, Département de Biologie Cellulaire et de l’Infection, Institut Pasteur, Paris, France

  ⨯
• Carlos M. Guardia,

  Roles Resources, Writing – review & editing

  Affiliation Neurosciences and Cellular and Structural Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0002-4662-9360

  ⨯
• Takashi Nonaka,

  Roles Resources

  Affiliation Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

  https://orcid.org/0000-0002-0830-9403

  ⨯
• Nalan Liv,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Section Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands

  ⨯
• Patricia Latour-Lambert,

  Roles Methodology

  Affiliation Dynamique des Interaction Hôte–Pathogène, Département de Biologie Cellulaire et de l’Infection, Institut Pasteur, Paris, France

  ⨯
• Masato Hasegawa,

  Roles Resources

  Affiliation Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

  ⨯
• Judith Klumperman,

  Roles Data curation, Formal analysis

  Affiliation Section Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands

  https://orcid.org/0000-0003-4835-6228

  ⨯
• Juan S. Bonifacino,

  Roles Resources, Writing – review & editing

  Affiliation Neurosciences and Cellular and Structural Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Chiara Zurzolo

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: chiara.zurzolo@pasteur.fr

  Affiliation Unité de Trafic Membranaire et Pathogénèse, Département de Biologie Cellulaire et de l’Infection, Institut Pasteur, Paris, France

  https://orcid.org/0000-0001-6048-6602

  ⨯