A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors

• Alba Corman,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

  https://orcid.org/0000-0001-8133-8967

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• Dimitris C. Kanellis,

  Roles Investigation, Methodology

  Affiliation Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

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• Patrycja Michalska,

  Roles Investigation

  Affiliation Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

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• Maria Häggblad,

  Roles Investigation

  Affiliation Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

  https://orcid.org/0000-0002-3857-1437

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• Vanesa Lafarga,

  Roles Investigation

  Affiliation Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

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• Jiri Bartek,

  Roles Formal analysis, Writing – review & editing

  Affiliations Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden, Danish Cancer Society Research Center, Copenhagen, Denmark

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• Jordi Carreras-Puigvert ,

  Roles Formal analysis, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: jordi.carreras.puigvert@farmbio.uu.se (JC-P); oscar.fernandez-capetillo@ki.se (OF-C)

  Current address: Department of Pharmaceutical Biosciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

  Affiliation Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

  https://orcid.org/0000-0002-7671-3707

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• Oscar Fernandez-Capetillo

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jordi.carreras.puigvert@farmbio.uu.se (JC-P); oscar.fernandez-capetillo@ki.se (OF-C)

  Affiliations Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden, Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

  https://orcid.org/0000-0002-2690-6885

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