Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease–related pathology

• Feng Han,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft

  Affiliation Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania, United States of America

  https://orcid.org/0000-0003-3561-4304

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• Jing Chen,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Aaron Belkin-Rosen,

  Roles Data curation, Formal analysis, Investigation, Visualization

  Affiliation Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Yameng Gu,

  Roles Formal analysis, Investigation, Visualization

  Affiliation Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Liying Luo,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliations Department of Sociology & Criminology, The Pennsylvania State University, University Park, Pennsylvania, United States of America, Population Research Institute, The Pennsylvania State University, University Park, Pennsylvania, United States of America

  https://orcid.org/0000-0001-5393-6695

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• Orfeu M. Buxton,

  Roles Visualization, Writing – review & editing

  Affiliation Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Xiao Liu ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: xxl213@engr.psu.edu

  Affiliations Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania, United States of America, Institute for Computational and Data Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America

  https://orcid.org/0000-0002-8459-3135

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• the Alzheimer’s Disease Neuroimaging Initiative