Integrated transcriptomics and epigenomics reveal chamber-specific and species-specific characteristics of human and mouse hearts

Junpeng Gao; Yuxuan Zheng; Lin Li; Minjie Lu; Xiangjian Chen; Yu Wang; Yanna Li; Xiaomeng Liu; Yun Gao; Yunuo Mao; Peng Zhao; Jinan Zhang; Fuchou Tang; Lei Song; Lu Wen; Jizheng Wang

doi:10.1371/journal.pbio.3001229

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Peer-reviewed

Methods and Resources report novel methods, substantial improvements to current methodologies, or informational datasets.

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Integrated transcriptomics and epigenomics reveal chamber-specific and species-specific characteristics of human and mouse hearts

Junpeng Gao ,

Contributed equally to this work with: Junpeng Gao, Yuxuan Zheng

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Beijing Advanced Innovation Center for Genomics, School of Life Sciences, Peking University, Beijing, China, Biomedical Pioneering Innovation Center, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing, China
⨯
Yuxuan Zheng ,

Contributed equally to this work with: Junpeng Gao, Yuxuan Zheng

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliations Beijing Advanced Innovation Center for Genomics, School of Life Sciences, Peking University, Beijing, China, Biomedical Pioneering Innovation Center, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing, China, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China

https://orcid.org/0000-0002-7407-5684

⨯
Lin Li,

Roles Investigation

Affiliation Guangdong Provincial Key Laboratory of Proteomics, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯
Minjie Lu,

Roles Investigation

Affiliation State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Xiangjian Chen,

Roles Investigation

Affiliation Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
⨯
Yu Wang,

Roles Investigation

Affiliation Department of Ultrasound, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, China
⨯
Yanna Li,

Roles Investigation

Affiliation Department of Obstetric and Gynecology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
⨯
Xiaomeng Liu,

Roles Investigation

Affiliation Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory Of Sichuan Province, Chengdu, China
⨯
Yun Gao,

Roles Investigation

Affiliations Beijing Advanced Innovation Center for Genomics, School of Life Sciences, Peking University, Beijing, China, Biomedical Pioneering Innovation Center, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing, China
⨯
Yunuo Mao,

Roles Investigation

Affiliations Beijing Advanced Innovation Center for Genomics, School of Life Sciences, Peking University, Beijing, China, Biomedical Pioneering Innovation Center, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing, China
⨯
Peng Zhao,

Roles Investigation

Affiliation Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, China
⨯
Jinan Zhang,

Roles Investigation

Affiliation Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
⨯
Fuchou Tang,

Roles Conceptualization, Funding acquisition, Investigation, Project administration

Affiliations Beijing Advanced Innovation Center for Genomics, School of Life Sciences, Peking University, Beijing, China, Biomedical Pioneering Innovation Center, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing, China, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
⨯
Lei Song ,

Roles Funding acquisition, Investigation, Supervision, Writing – review & editing

* E-mail: songlqd@126.com (LS); wenlu@pku.edu.cn (LW); jzwang@hotmail.com (JW)

Affiliations State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Lu Wen ,

Roles Funding acquisition, Investigation, Writing – review & editing

* E-mail: songlqd@126.com (LS); wenlu@pku.edu.cn (LW); jzwang@hotmail.com (JW)

Affiliations Beijing Advanced Innovation Center for Genomics, School of Life Sciences, Peking University, Beijing, China, Biomedical Pioneering Innovation Center, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing, China
⨯
[ ... ],
Jizheng Wang

Roles Data curation, Funding acquisition, Investigation, Supervision, Writing – review & editing

* E-mail: songlqd@126.com (LS); wenlu@pku.edu.cn (LW); jzwang@hotmail.com (JW)

Affiliation State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

https://orcid.org/0000-0002-2961-524X

⨯
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Integrated transcriptomics and epigenomics reveal chamber-specific and species-specific characteristics of human and mouse hearts

Junpeng Gao,
Yuxuan Zheng,
Lin Li,
Minjie Lu,
Xiangjian Chen,
Yu Wang,
Yanna Li,
Xiaomeng Liu,
Yun Gao,
Yunuo Mao

Published: May 18, 2021
https://doi.org/10.1371/journal.pbio.3001229

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