Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes

• Dan Fu ,

  Contributed equally to this work with: Dan Fu, Guangshun Zhang, Yuhui Wang, Zheng Zhang, Hengrui Hu, Shu Shen, Jun Wu, Bo Li, Xin Li

  Roles Investigation, Methodology, Validation

  Affiliation State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China

  ⨯
• Guangshun Zhang ,

  Contributed equally to this work with: Dan Fu, Guangshun Zhang, Yuhui Wang, Zheng Zhang, Hengrui Hu, Shu Shen, Jun Wu, Bo Li, Xin Li

  Roles Investigation, Methodology, Software, Validation, Visualization

  Affiliations State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China, Harbour Biomed (Suzhou) Co. Ltd., Suzhou Industrial Park, Suzhou, China, College of Life Science, Nankai University, Tianjin, China

  ⨯
• Yuhui Wang ,

  Contributed equally to this work with: Dan Fu, Guangshun Zhang, Yuhui Wang, Zheng Zhang, Hengrui Hu, Shu Shen, Jun Wu, Bo Li, Xin Li

  Roles Investigation, Methodology

  Affiliations State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China, College of Life Science, Nankai University, Tianjin, China

  ⨯
• Zheng Zhang ,

  Contributed equally to this work with: Dan Fu, Guangshun Zhang, Yuhui Wang, Zheng Zhang, Hengrui Hu, Shu Shen, Jun Wu, Bo Li, Xin Li

  Roles Investigation, Methodology

  Affiliation State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China

  ⨯
• Hengrui Hu ,

  Contributed equally to this work with: Dan Fu, Guangshun Zhang, Yuhui Wang, Zheng Zhang, Hengrui Hu, Shu Shen, Jun Wu, Bo Li, Xin Li

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliations Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

  ⨯
• Shu Shen ,

  Contributed equally to this work with: Dan Fu, Guangshun Zhang, Yuhui Wang, Zheng Zhang, Hengrui Hu, Shu Shen, Jun Wu, Bo Li, Xin Li

  Roles Investigation, Methodology

  Affiliations Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

  ⨯
• Jun Wu ,

  Contributed equally to this work with: Dan Fu, Guangshun Zhang, Yuhui Wang, Zheng Zhang, Hengrui Hu, Shu Shen, Jun Wu, Bo Li, Xin Li

  Roles Data curation, Investigation, Methodology, Software, Visualization, Writing – original draft

  Affiliation Harbour Biomed (Suzhou) Co. Ltd., Suzhou Industrial Park, Suzhou, China

  https://orcid.org/0000-0002-4457-5485

  ⨯
• Bo Li ,

  Contributed equally to this work with: Dan Fu, Guangshun Zhang, Yuhui Wang, Zheng Zhang, Hengrui Hu, Shu Shen, Jun Wu, Bo Li, Xin Li

  Roles Investigation, Methodology

  Affiliations State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China, College of Life Science, Nankai University, Tianjin, China

  ⨯
• Xin Li ,

  Contributed equally to this work with: Dan Fu, Guangshun Zhang, Yuhui Wang, Zheng Zhang, Hengrui Hu, Shu Shen, Jun Wu, Bo Li, Xin Li

  Roles Investigation, Methodology, Software, Visualization

  Affiliations State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China, College of Life Science, Nankai University, Tianjin, China, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China

  ⨯
• Yaohui Fang,

  Roles Investigation, Methodology

  Affiliation State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

  ⨯
• Jia Liu,

  Roles Investigation, Methodology

  Affiliation Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

  ⨯
• Qiao Wang,

  Roles Investigation, Methodology, Resources, Supervision

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China

  ⨯
• Yunjiao Zhou,

  Roles Investigation, Methodology

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China

  https://orcid.org/0000-0002-0937-3570

  ⨯
• Wei Wang,

  Roles Investigation, Methodology

  Affiliation Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China

  ⨯
• Yufeng Li,

  Roles Methodology, Project administration

  Affiliation Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

  ⨯
• Zhonghua Lu,

  Roles Investigation, Methodology, Software

  Affiliation Harbour Biomed (Suzhou) Co. Ltd., Suzhou Industrial Park, Suzhou, China

  ⨯
• Xiaoxiao Wang,

  Roles Investigation, Methodology, Supervision

  Affiliation Harbour Biomed (Suzhou) Co. Ltd., Suzhou Industrial Park, Suzhou, China

  ⨯
• Cui Nie,

  Roles Investigation, Methodology

  Affiliation Harbour Biomed (Suzhou) Co. Ltd., Suzhou Industrial Park, Suzhou, China

  ⨯
• Yujie Tian,

  Roles Investigation, Methodology

  Affiliations State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China, Frontiers Science Center for Cell Responses, Nankai University, Tianjin, China

  ⨯
• Da Chen,

  Roles Methodology, Project administration, Software, Visualization

  Affiliations State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China, College of Life Science, Nankai University, Tianjin, China, Frontiers Science Center for Cell Responses, Nankai University, Tianjin, China

  ⨯
• Yuan Wang,

  Roles Investigation, Methodology, Supervision

  Affiliations State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China, College of Life Science, Nankai University, Tianjin, China, Frontiers Science Center for Cell Responses, Nankai University, Tianjin, China

  ⨯
• Xingdong Zhou,

  Roles Investigation, Methodology

  Affiliations State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China, College of Life Science, Nankai University, Tianjin, China, Frontiers Science Center for Cell Responses, Nankai University, Tianjin, China

  ⨯
• Qisheng Wang,

  Roles Software, Supervision, Validation, Visualization

  Affiliation Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China

  ⨯
• Feng Yu,

  Roles Investigation, Methodology, Software

  Affiliation Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China

  ⨯
• Chen Zhang,

  Roles Investigation, Methodology

  Affiliation State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China

  ⨯
• Changjing Deng,

  Roles Investigation, Methodology

  Affiliation Harbour Biomed (Suzhou) Co. Ltd., Suzhou Industrial Park, Suzhou, China

  ⨯
• Liang Zhou,

  Roles Investigation, Methodology

  Affiliation Harbour Biomed (Suzhou) Co. Ltd., Suzhou Industrial Park, Suzhou, China

  ⨯
• Guangkuo Guan,

  Roles Investigation, Methodology

  Affiliation Harbour Biomed (Suzhou) Co. Ltd., Suzhou Industrial Park, Suzhou, China

  ⨯
• Na Shao,

  Roles Investigation, Methodology

  Affiliation Harbour Biomed (Suzhou) Co. Ltd., Suzhou Industrial Park, Suzhou, China

  ⨯
• Zhiyong Lou ,

  Roles Conceptualization, Project administration, Resources

  * E-mail: louzy@mail.tsinghua.edu.cn (ZL); df@wh.iov.cn (FD); hongkai@nankai.edu.cn (HZ); chen_xinwen@gibh.ac.cn (XC); wangml@wh.iov.cn (MW); Louis.Liu@harbourbiomed.com (LL); raozh@mail.tsinghua.edu.cn (ZR); guoyu@nankai.edu.cn (YG)

  Affiliation MOE Key Laboratory of Protein Science & Collaborative Innovation Center of Biotherapy, School of Medicine, Tsinghua University, Beijing, China

  ⨯
• Fei Deng ,

  Roles Investigation, Methodology, Project administration, Supervision

  * E-mail: louzy@mail.tsinghua.edu.cn (ZL); df@wh.iov.cn (FD); hongkai@nankai.edu.cn (HZ); chen_xinwen@gibh.ac.cn (XC); wangml@wh.iov.cn (MW); Louis.Liu@harbourbiomed.com (LL); raozh@mail.tsinghua.edu.cn (ZR); guoyu@nankai.edu.cn (YG)

  Affiliations Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

  ⨯
• Hongkai Zhang ,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

  * E-mail: louzy@mail.tsinghua.edu.cn (ZL); df@wh.iov.cn (FD); hongkai@nankai.edu.cn (HZ); chen_xinwen@gibh.ac.cn (XC); wangml@wh.iov.cn (MW); Louis.Liu@harbourbiomed.com (LL); raozh@mail.tsinghua.edu.cn (ZR); guoyu@nankai.edu.cn (YG)

  Affiliations State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China, Frontiers Science Center for Cell Responses, Nankai University, Tianjin, China

  ⨯
• Xinwen Chen ,

  Roles Conceptualization, Investigation, Resources, Writing – original draft

  * E-mail: louzy@mail.tsinghua.edu.cn (ZL); df@wh.iov.cn (FD); hongkai@nankai.edu.cn (HZ); chen_xinwen@gibh.ac.cn (XC); wangml@wh.iov.cn (MW); Louis.Liu@harbourbiomed.com (LL); raozh@mail.tsinghua.edu.cn (ZR); guoyu@nankai.edu.cn (YG)

  Affiliations Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, Guangzhou Laboratory, Guangzhou International Bio-Island, Guangzhou, Guangdong, China

  ⨯
• Manli Wang ,

  Roles Investigation, Methodology, Supervision, Writing – review & editing

  * E-mail: louzy@mail.tsinghua.edu.cn (ZL); df@wh.iov.cn (FD); hongkai@nankai.edu.cn (HZ); chen_xinwen@gibh.ac.cn (XC); wangml@wh.iov.cn (MW); Louis.Liu@harbourbiomed.com (LL); raozh@mail.tsinghua.edu.cn (ZR); guoyu@nankai.edu.cn (YG)

  Affiliation Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

  ⨯
• Louis Liu ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology

  * E-mail: louzy@mail.tsinghua.edu.cn (ZL); df@wh.iov.cn (FD); hongkai@nankai.edu.cn (HZ); chen_xinwen@gibh.ac.cn (XC); wangml@wh.iov.cn (MW); Louis.Liu@harbourbiomed.com (LL); raozh@mail.tsinghua.edu.cn (ZR); guoyu@nankai.edu.cn (YG)

  Affiliation Harbour Biomed (Suzhou) Co. Ltd., Suzhou Industrial Park, Suzhou, China

  ⨯
• Zihe Rao ,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft

  * E-mail: louzy@mail.tsinghua.edu.cn (ZL); df@wh.iov.cn (FD); hongkai@nankai.edu.cn (HZ); chen_xinwen@gibh.ac.cn (XC); wangml@wh.iov.cn (MW); Louis.Liu@harbourbiomed.com (LL); raozh@mail.tsinghua.edu.cn (ZR); guoyu@nankai.edu.cn (YG)

  Affiliations State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China, College of Life Science, Nankai University, Tianjin, China, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China

  ⨯
•  [ ... ],
• Yu Guo

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: louzy@mail.tsinghua.edu.cn (ZL); df@wh.iov.cn (FD); hongkai@nankai.edu.cn (HZ); chen_xinwen@gibh.ac.cn (XC); wangml@wh.iov.cn (MW); Louis.Liu@harbourbiomed.com (LL); raozh@mail.tsinghua.edu.cn (ZR); guoyu@nankai.edu.cn (YG)

  Affiliations State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China, Frontiers Science Center for Cell Responses, Nankai University, Tianjin, China, Guangzhou Laboratory, Guangzhou International Bio-Island, Guangzhou, Guangdong, China

  https://orcid.org/0000-0002-8109-7515

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