Pathogenic missense protein variants affect different functional pathways and proteomic features than healthy population variants

• Anna Laddach ,

  Contributed equally to this work with: Anna Laddach, Joseph Chi Fung Ng

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: The Francis Crick Institute, London, United Kingdom

  ¶‡ These authors share first authorship on this work.

  Affiliation Randall Centre for Cell and Molecular Biophysics, King’s College London, London, United Kingdom

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• Joseph Chi Fung Ng ,

  Contributed equally to this work with: Anna Laddach, Joseph Chi Fung Ng

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliation Randall Centre for Cell and Molecular Biophysics, King’s College London, London, United Kingdom

  https://orcid.org/0000-0002-3617-5211

  ⨯
• Franca Fraternali

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: franca.fraternali@kcl.ac.uk

  Affiliation Randall Centre for Cell and Molecular Biophysics, King’s College London, London, United Kingdom

  https://orcid.org/0000-0002-3143-6574

  ⨯