Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

• Corvin D. Arveseth ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ CDA and JTH are co-first authors on this work. DSH and J-FZ are co-second authors on this work.

  Affiliation Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  https://orcid.org/0000-0003-1769-1162

  ⨯
• John T. Happ ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ CDA and JTH are co-first authors on this work. DSH and J-FZ are co-second authors on this work.

  Affiliation Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  ⨯
• Danielle S. Hedeen ,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  ¶‡ CDA and JTH are co-first authors on this work. DSH and J-FZ are co-second authors on this work.

  Affiliation Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  ⨯
• Ju-Fen Zhu ,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  ¶‡ CDA and JTH are co-first authors on this work. DSH and J-FZ are co-second authors on this work.

  Affiliation Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  https://orcid.org/0000-0002-9903-5240

  ⨯
• Jacob L. Capener,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  ⨯
• Dana Klatt Shaw,

  Roles Investigation, Validation, Writing – review & editing

  Current address: Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

  Affiliation Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  https://orcid.org/0000-0003-3299-3070

  ⨯
• Ishan Deshpande,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Department of Pharmaceutical Chemistry, Department of Anaesthesia and Perioperative Care, University of California, San Francisco, California, United States of America

  ⨯
• Jiahao Liang,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Department of Pharmaceutical Chemistry, Department of Anaesthesia and Perioperative Care, University of California, San Francisco, California, United States of America

  ⨯
• Jiewei Xu,

  Roles Investigation, Validation, Writing – review & editing

  Affiliations Department of Cellular and Molecular Pharmacology, Quantitative Biosciences Institute, University of California, San Francisco, California, United States of America, J. David Gladstone Institutes, San Francisco, California, United States of America

  ⨯
• Sara L. Stubben,

  Roles Investigation, Validation, Writing – review & editing

  Current address: Department of Plant and Wildlife Sciences, College of Life Sciences, Brigham Young University, Provo, Utah, United States of America

  Affiliation Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  ⨯
• Isaac B. Nelson,

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  https://orcid.org/0000-0003-1861-0619

  ⨯
• Madison F. Walker,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  ⨯
• Kouki Kawakami,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan

  ⨯
• Asuka Inoue,

  Roles Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan

  ⨯
• Nevan J. Krogan,

  Roles Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliations Department of Cellular and Molecular Pharmacology, Quantitative Biosciences Institute, University of California, San Francisco, California, United States of America, J. David Gladstone Institutes, San Francisco, California, United States of America

  ⨯
• David J. Grunwald,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – review & editing

  Affiliation Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  ⨯
• Ruth Hüttenhain,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Validation, Writing – review & editing

  Affiliations Department of Cellular and Molecular Pharmacology, Quantitative Biosciences Institute, University of California, San Francisco, California, United States of America, J. David Gladstone Institutes, San Francisco, California, United States of America

  https://orcid.org/0000-0002-0896-5910

  ⨯
• Aashish Manglik,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – review & editing

  Affiliation Department of Pharmaceutical Chemistry, Department of Anaesthesia and Perioperative Care, University of California, San Francisco, California, United States of America

  ⨯
•  [ ... ],
• Benjamin R. Myers

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: benjamin.myers@hci.utah.edu

  Affiliation Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  https://orcid.org/0000-0003-0975-539X

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