Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells

• Josep Biayna,

  Roles Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Genome Data Science, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain

  https://orcid.org/0000-0002-0842-7530

  ⨯
• Isabel Garcia-Cao,

  Roles Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Genomic Instability and Cancer, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain

  https://orcid.org/0000-0002-4582-0403

  ⨯
• Miguel M. Álvarez,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Genome Data Science, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain

  ⨯
• Marina Salvadores,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Genome Data Science, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain

  https://orcid.org/0000-0002-7850-7691

  ⨯
• Jose Espinosa-Carrasco,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Genome Data Science, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain

  https://orcid.org/0000-0002-1541-042X

  ⨯
• Marcel McCullough,

  Roles Investigation

  Affiliation Genome Data Science, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain

  https://orcid.org/0000-0002-1001-8920

  ⨯
• Fran Supek ,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: fran.supek@irbbarcelona.org (FS); travis.stracker@nih.gov (THS)

  Affiliations Genome Data Science, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain, Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain

  https://orcid.org/0000-0002-7811-6711

  ⨯
• Travis H. Stracker

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: fran.supek@irbbarcelona.org (FS); travis.stracker@nih.gov (THS)

  Affiliations Genomic Instability and Cancer, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain, National Cancer Institute, Center for Cancer Research, Radiation Oncology Branch, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0002-8650-2081

  ⨯