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Open Access
Peer-reviewed
Research Article
Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium
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Philip V’kovski ,
Contributed equally to this work with: Philip V’kovski, Mitra Gultom, Jenna N. Kelly, Silvio Steiner
Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations Institute of Virology and Immunology (IVI), Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
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Mitra Gultom ,
Contributed equally to this work with: Philip V’kovski, Mitra Gultom, Jenna N. Kelly, Silvio Steiner
Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing
Affiliations Institute of Virology and Immunology (IVI), Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland, Graduate School for Biomedical Science, University of Bern, Bern, Switzerland, Institute for Infectious Diseases, University of Bern, Bern, Switzerland
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Jenna N. Kelly ,
Contributed equally to this work with: Philip V’kovski, Mitra Gultom, Jenna N. Kelly, Silvio Steiner
Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing
Affiliations Institute of Virology and Immunology (IVI), Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
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Silvio Steiner ,
Contributed equally to this work with: Philip V’kovski, Mitra Gultom, Jenna N. Kelly, Silvio Steiner
Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing
Affiliations Institute of Virology and Immunology (IVI), Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland, Graduate School for Biomedical Science, University of Bern, Bern, Switzerland
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Julie Russeil,
Roles Investigation
Affiliation Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
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Bastien Mangeat,
Roles Investigation
Affiliation Gene Expression Core Facility (GECF), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
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Elisa Cora,
Roles Investigation
Affiliation Gene Expression Core Facility (GECF), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
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Joern Pezoldt,
Roles Investigation
Affiliation Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
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Melle Holwerda,
Roles Investigation
Affiliations Institute of Virology and Immunology (IVI), Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland, Graduate School for Biomedical Science, University of Bern, Bern, Switzerland, Institute for Infectious Diseases, University of Bern, Bern, Switzerland
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Annika Kratzel,
Roles Investigation
Affiliations Institute of Virology and Immunology (IVI), Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland, Graduate School for Biomedical Science, University of Bern, Bern, Switzerland
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Laura Laloli,
Roles Investigation
Affiliations Graduate School for Biomedical Science, University of Bern, Bern, Switzerland, Institute for Infectious Diseases, University of Bern, Bern, Switzerland
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Manon Wider,
Roles Investigation
Affiliation Institute for Infectious Diseases, University of Bern, Bern, Switzerland
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Jasmine Portmann,
Roles Investigation
Affiliations Institute of Virology and Immunology (IVI), Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
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Thao Tran,
Roles Investigation
Affiliations Institute of Virology and Immunology (IVI), Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland, Graduate School for Biomedical Science, University of Bern, Bern, Switzerland
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Nadine Ebert,
Roles Investigation
Affiliations Institute of Virology and Immunology (IVI), Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
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Hanspeter Stalder,
Roles Investigation
Affiliations Institute of Virology and Immunology (IVI), Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
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Rune Hartmann,
Roles Resources
Affiliation Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
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Vincent Gardeux,
Roles Supervision
Affiliations Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland
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Daniel Alpern,
Roles Supervision
Affiliations Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland
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Bart Deplancke,
Roles Supervision
Affiliations Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland
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Volker Thiel,
Roles Funding acquisition, Supervision, Writing – review & editing
Affiliations Institute of Virology and Immunology (IVI), Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
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Ronald Dijkman
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: ronald.dijkman@ifik.unibe.ch
Affiliations Institute of Virology and Immunology (IVI), Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland, Institute for Infectious Diseases, University of Bern, Bern, Switzerland
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Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium
- Philip V’kovski,
- Mitra Gultom,
- Jenna N. Kelly,
- Silvio Steiner,
- Julie Russeil,
- Bastien Mangeat,
- Elisa Cora,
- Joern Pezoldt,
- Melle Holwerda,
- Annika Kratzel

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- Published: March 29, 2021
- https://doi.org/10.1371/journal.pbio.3001158