A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2

• Kwang Su Kim ,

  Contributed equally to this work with: Kwang Su Kim, Keisuke Ejima

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan

  https://orcid.org/0000-0001-6626-316X

  ⨯
• Keisuke Ejima ,

  Contributed equally to this work with: Kwang Su Kim, Keisuke Ejima

  Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Epidemiology and Biostatistics, Indiana University School of Public Health–Bloomington, Bloomington, Indiana, United States of America

  https://orcid.org/0000-0002-1185-3987

  ⨯
• Shoya Iwanami,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan

  https://orcid.org/0000-0003-1474-5348

  ⨯
• Yasuhisa Fujita,

  Roles Conceptualization, Investigation, Writing – original draft

  Affiliation Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan

  https://orcid.org/0000-0002-1720-3942

  ⨯
• Hirofumi Ohashi,

  Roles Investigation, Writing – original draft

  Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

  ⨯
• Yoshiki Koizumi,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation National Center for Global Health and Medicine, Tokyo, Japan

  ⨯
• Yusuke Asai,

  Roles Investigation, Writing – original draft

  Affiliation National Center for Global Health and Medicine, Tokyo, Japan

  ⨯
• Shinji Nakaoka,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan

  ⨯
• Koichi Watashi,

  Roles Investigation, Writing – original draft

  Affiliations Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, Department of Applied Biological Science, Tokyo University of Science, Noda, Japan, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, JST-Mirai, Japan Science and Technology Agency, Saitama, Japan

  ⨯
• Kazuyuki Aihara,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation International Research Center for Neurointelligence, University of Tokyo Institutes for Advanced Study, University of Tokyo, Tokyo, Japan

  ⨯
• Robin N. Thompson,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliations Mathematics Institute, University of Warwick, Coventry, United Kingdom, Zeeman Institute for Systems Biology and Infectious Disease Epidemiology Research, University of Warwick, Coventry, United Kingdom

  https://orcid.org/0000-0001-8545-5212

  ⨯
• Ruian Ke,

  Roles Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations New Mexico Consortium, Los Alamos, New Mexico, United States of America, Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

  https://orcid.org/0000-0001-5307-8934

  ⨯
• Alan S. Perelson ,

  Roles Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: asp@lanl.gov (ASP); siwami@kyushu-u.org (SI)

  ¶‡ These authors are joint senior authors on this work.

  Affiliations New Mexico Consortium, Los Alamos, New Mexico, United States of America, Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

  https://orcid.org/0000-0002-2455-0002

  ⨯
• Shingo Iwami

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: asp@lanl.gov (ASP); siwami@kyushu-u.org (SI)

  ¶‡ These authors are joint senior authors on this work.

  Affiliations Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan, JST-Mirai, Japan Science and Technology Agency, Saitama, Japan, Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan, NEXT-Ganken Program, Japanese Foundation for Cancer Research, Tokyo, Japan, Science Groove, Fukuoka, Japan

  https://orcid.org/0000-0002-1780-350X

  ⨯