Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen

• Oscar A. MacLean ,

  Contributed equally to this work with: Oscar A. MacLean, Spyros Lytras

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom

  https://orcid.org/0000-0003-4919-4697

  ⨯
• Spyros Lytras ,

  Contributed equally to this work with: Oscar A. MacLean, Spyros Lytras

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom

  ⨯
• Steven Weaver,

  Roles Formal analysis, Investigation, Resources, Software

  Affiliation Temple University, Institute for Genomics and Evolutionary Medicine, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-6931-7191

  ⨯
• Joshua B. Singer,

  Roles Data curation, Resources, Software

  Affiliation MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom

  https://orcid.org/0000-0001-6989-475X

  ⨯
• Maciej F. Boni,

  Roles Data curation, Funding acquisition, Methodology, Writing – review & editing

  Affiliation Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

  ⨯
• Philippe Lemey,

  Roles Formal analysis, Funding acquisition, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

  ⨯
• Sergei L. Kosakovsky Pond ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: spond@temple.edu (SLKP); david.l.robertson@glasgow.ac.uk (DLR)

  Affiliation Temple University, Institute for Genomics and Evolutionary Medicine, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0003-4817-4029

  ⨯
• David L. Robertson

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: spond@temple.edu (SLKP); david.l.robertson@glasgow.ac.uk (DLR)

  Affiliation MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom

  https://orcid.org/0000-0001-6338-0221

  ⨯