Noncanonical TGF-β signaling leads to FBXO3-mediated degradation of ΔNp63α promoting breast cancer metastasis and poor clinical prognosis

• Mengmeng Niu ,

  Contributed equally to this work with: Mengmeng Niu, Yajun He

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: niumm@scu.edu.cn (MN); jimzx@scu.edu.cn (Z-XJX)

  Affiliation Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

  ⨯
• Yajun He ,

  Contributed equally to this work with: Mengmeng Niu, Yajun He

  Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

  ⨯
• Jing Xu,

  Roles Data curation, Methodology

  Affiliation Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

  ⨯
• Liangping Ding,

  Roles Data curation, Methodology

  Affiliation Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

  ⨯
• Tao He,

  Roles Data curation, Methodology

  Affiliation Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

  ⨯
• Yong Yi,

  Roles Data curation, Formal analysis, Funding acquisition, Methodology

  Affiliation Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

  https://orcid.org/0000-0003-4664-9692

  ⨯
• Mengyuan Fu,

  Roles Data curation, Methodology

  Affiliation Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

  ⨯
• Rongtian Guo,

  Roles Data curation

  Affiliation Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

  ⨯
• Fengtian Li,

  Roles Data curation, Methodology, Software

  Affiliation Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

  ⨯
• Hu Chen,

  Roles Formal analysis, Software

  Affiliation Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

  https://orcid.org/0000-0001-8136-7442

  ⨯
• Ye-Guang Chen,

  Roles Conceptualization

  Affiliation The State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China

  ⨯
• Zhi-Xiong Jim Xiao

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: niumm@scu.edu.cn (MN); jimzx@scu.edu.cn (Z-XJX)

  Affiliations Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China

  https://orcid.org/0000-0003-2504-5742

  ⨯