The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis

• Patrick A. Carroll,

  Roles Conceptualization, Data curation, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  https://orcid.org/0000-0001-8147-5750

  ⨯
• Brian W. Freie,

  Roles Data curation, Formal analysis

  Affiliation Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-1450-865X

  ⨯
• Pei Feng Cheng,

  Roles Investigation

  Affiliation Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  ⨯
• Sivakanthan Kasinathan,

  Roles Formal analysis, Methodology

  Affiliation Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-2218-6371

  ⨯
• Haiwei Gu,

  Roles Conceptualization, Formal analysis, Investigation, Methodology

  Affiliation Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-7598-5022

  ⨯
• Theresa Hedrich,

  Roles Investigation

  Affiliation Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-6952-1643

  ⨯
• James A. Dowdle,

  Roles Conceptualization

  Affiliation Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America

  https://orcid.org/0000-0002-1780-2208

  ⨯
• Vivek Venkataramani,

  Roles Conceptualization, Investigation, Methodology

  Affiliation Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany

  https://orcid.org/0000-0002-6771-365X

  ⨯
• Vijay Ramani,

  Roles Conceptualization

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-3345-5960

  ⨯
• Xiaoying Wu,

  Roles Investigation, Visualization

  Affiliation Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  ⨯
• Daniel Raftery,

  Roles Funding acquisition, Supervision

  Affiliation Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-2467-8118

  ⨯
• Jay Shendure,

  Roles Supervision

  Affiliations Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America, Brotman Baty Institute for Precision Medicine, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-1516-1865

  ⨯
• Donald E. Ayer,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America

  https://orcid.org/0000-0002-5595-3269

  ⨯
• Charles H. Muller,

  Roles Conceptualization, Investigation, Methodology, Supervision

  Affiliation Male Fertility Lab, Department of Urology, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-1593-2073

  ⨯
• Robert N. Eisenman

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: eisenman@fredhutch.org

  Affiliation Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-0274-9846

  ⨯