Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels

Barbora Waclawiková; Amber Bullock; Markus Schwalbe; Carmen Aranzamendi; Sieger A. Nelemans; Gertjan van Dijk; Sahar El Aidy

doi:10.1371/journal.pbio.3001070

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Open Access

Peer-reviewed

Research Article

Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels

Barbora Waclawiková,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft

Affiliation Host-Microbe Metabolic Interactions, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, the Netherlands
⨯
Amber Bullock,

Roles Methodology, Writing – review & editing

Affiliation Host-Microbe Metabolic Interactions, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, the Netherlands
⨯
Markus Schwalbe,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Host-Microbe Metabolic Interactions, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, the Netherlands
⨯
Carmen Aranzamendi,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Host-Microbe Metabolic Interactions, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, the Netherlands
⨯
Sieger A. Nelemans,

Roles Methodology, Writing – review & editing

Affiliation Department of Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, the Netherlands
⨯
Gertjan van Dijk,

Roles Methodology, Visualization, Writing – review & editing

Affiliation Department of Behavioral Neurosciences, Cluster Neurobiology, Groningen Institute of for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, The Netherlands
⨯
Sahar El Aidy

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: sahar.elaidy@rug.nl

Affiliation Host-Microbe Metabolic Interactions, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, the Netherlands

https://orcid.org/0000-0001-8950-4392

⨯

Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels

Barbora Waclawiková,
Amber Bullock,
Markus Schwalbe,
Carmen Aranzamendi,
Sieger A. Nelemans,
Gertjan van Dijk,
Sahar El Aidy

Published: January 22, 2021
https://doi.org/10.1371/journal.pbio.3001070

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Colon
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