Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defenses

Vanessa Herder; Kieran Dee; Joanna K. Wojtus; Ilaria Epifano; Daniel Goldfarb; Christoforos Rozario; Quan Gu; Ana Da Silva Filipe; Kyriaki Nomikou; Jenna Nichols; Ruth F. Jarrett; Andrew Stevenson; Steven McFarlane; Meredith E. Stewart; Agnieszka M. Szemiel; Rute M. Pinto; Andreu Masdefiol Garriga; Chris Davis; Jay Allan; Sheila V. Graham; Pablo R. Murcia; Chris Boutell

doi:10.1371/journal.pbio.3001065

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Open Access

Peer-reviewed

Research Article

Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defenses

Vanessa Herder ,

Contributed equally to this work with: Vanessa Herder, Kieran Dee

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0003-4814-1382

⨯
Kieran Dee ,

Contributed equally to this work with: Vanessa Herder, Kieran Dee

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0002-3280-6768

⨯
Joanna K. Wojtus,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0003-4345-3475

⨯
Ilaria Epifano,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0002-2056-0510

⨯
Daniel Goldfarb,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0001-6014-387X

⨯
Christoforos Rozario,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0003-2438-5219

⨯
Quan Gu,

Roles Data curation, Formal analysis, Methodology, Validation

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0002-1201-6734

⨯
Ana Da Silva Filipe,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0002-9442-2903

⨯
Kyriaki Nomikou,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom
⨯
Jenna Nichols,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0003-0093-7170

⨯
Ruth F. Jarrett,

Roles Conceptualization, Formal analysis, Methodology, Resources

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom
⨯
Andrew Stevenson,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0002-5325-5360

⨯
Steven McFarlane,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom
⨯
Meredith E. Stewart,

Roles Methodology, Resources

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0001-6275-2740

⨯
Agnieszka M. Szemiel,

Roles Methodology, Resources

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0003-3085-9994

⨯
Rute M. Pinto,

Roles Methodology, Resources

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0003-3291-1397

⨯
Andreu Masdefiol Garriga,

Roles Data curation, Formal analysis

Affiliations MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom, University of Glasgow School of Veterinary Medicine, Glasgow, Scotland United Kingdom

https://orcid.org/0000-0002-2094-3001

⨯
Chris Davis,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0002-7317-3266

⨯
Jay Allan,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0002-6482-7125

⨯
Sheila V. Graham ,

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: Sheila.Graham@glasgow.ac.uk (SVG); Pablo.Murcia@glasgow.ac.uk (PRM); chris.boutell@glasgow.ac.uk (CB)

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0002-7140-8279

⨯
Pablo R. Murcia ,

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: Sheila.Graham@glasgow.ac.uk (SVG); Pablo.Murcia@glasgow.ac.uk (PRM); chris.boutell@glasgow.ac.uk (CB)

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0002-4352-394X

⨯
[ ... ],
Chris Boutell

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: Sheila.Graham@glasgow.ac.uk (SVG); Pablo.Murcia@glasgow.ac.uk (PRM); chris.boutell@glasgow.ac.uk (CB)

Affiliation MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland United Kingdom

https://orcid.org/0000-0002-2970-7785

⨯
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Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defenses

Vanessa Herder,
Kieran Dee,
Joanna K. Wojtus,
Ilaria Epifano,
Daniel Goldfarb,
Christoforos Rozario,
Quan Gu,
Ana Da Silva Filipe,
Kyriaki Nomikou,
Jenna Nichols

Published: December 21, 2021
https://doi.org/10.1371/journal.pbio.3001065

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