Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart

• Diego Barriales,

  Roles Investigation, Visualization, Writing – original draft

  Affiliation Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain

  https://orcid.org/0000-0002-6433-3379

  ⨯
• Itziar Martín-Ruiz,

  Roles Investigation, Writing – review & editing

  Affiliation Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain

  ⨯
• Ana Carreras-González,

  Roles Investigation, Writing – review & editing

  Affiliation Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain

  ⨯
• Marta Montesinos-Robledo,

  Roles Investigation, Writing – review & editing

  Affiliation Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain

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• Mikel Azkargorta,

  Roles Formal analysis, Writing – review & editing

  Affiliation Proteomics Platform, ProteoRed-ISCIII, CIC bioGUNE-BRTA, Derio, Spain

  ⨯
• Ibon Iloro,

  Roles Investigation, Writing – review & editing

  Affiliation Proteomics Platform, ProteoRed-ISCIII, CIC bioGUNE-BRTA, Derio, Spain

  https://orcid.org/0000-0002-9537-1714

  ⨯
• Iraide Escobés,

  Roles Investigation, Writing – review & editing

  Affiliation Proteomics Platform, ProteoRed-ISCIII, CIC bioGUNE-BRTA, Derio, Spain

  ⨯
• Teresa Martín-Mateos,

  Roles Investigation, Writing – review & editing

  Affiliation Physiopathology of the Hypoxia-Signaling Pathway Laboratory, CIC bioGUNE-BRTA, Derio, Spain

  ⨯
• Estibaliz Atondo,

  Roles Investigation, Writing – review & editing

  Affiliation Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain

  ⨯
• Ainhoa Palacios,

  Roles Investigation

  Affiliation Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain

  https://orcid.org/0000-0001-8945-5260

  ⨯
• Monika Gonzalez-Lopez,

  Roles Investigation, Writing – review & editing

  Affiliation Genomic Analysis Platform, CIC bioGUNE-BRTA, Derio, Spain

  https://orcid.org/0000-0003-1506-0332

  ⨯
• Laura Bárcena,

  Roles Investigation, Writing – review & editing

  Affiliation Genomic Analysis Platform, CIC bioGUNE-BRTA, Derio, Spain

  https://orcid.org/0000-0002-0513-0969

  ⨯
• Ana R. Cortázar,

  Roles Formal analysis, Writing – review & editing

  Affiliation Genomic Analysis Platform, CIC bioGUNE-BRTA, Derio, Spain

  ⨯
• Diana Cabrera,

  Roles Investigation, Writing – review & editing

  Affiliation Metabolomics Platform, CIC bioGUNE-BRTA, Derio, Spain

  ⨯
• Ainize Peña-Cearra,

  Roles Investigation, Writing – review & editing

  Affiliation Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain

  ⨯
• Sebastiaan M. van Liempd,

  Roles Investigation, Writing – review & editing

  Affiliation Metabolomics Platform, CIC bioGUNE-BRTA, Derio, Spain

  ⨯
• Juan M. Falcón-Pérez,

  Roles Formal analysis, Writing – review & editing

  Affiliations Metabolomics Platform, CIC bioGUNE-BRTA, Derio, Spain, Ikerbasque, Basque Foundation for Science, Bilbao, Spain

  https://orcid.org/0000-0003-3133-0670

  ⨯
• Miguel A. Pascual-Itoiz,

  Roles Investigation, Writing – review & editing

  Affiliation Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain

  ⨯
• Juana María Flores,

  Roles Investigation

  Affiliation Department of Animal Medicine and Surgery, Veterinary Faculty, Universidad Complutense de Madrid, Madrid, Spain

  https://orcid.org/0000-0002-7995-4426

  ⨯
• Leticia Abecia,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain

  https://orcid.org/0000-0003-4097-8903

  ⨯
• Aize Pellon,

  Roles Investigation, Writing – review & editing

  Affiliation Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain

  https://orcid.org/0000-0003-0415-6566

  ⨯
• Maria Luz Martínez-Chantar,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Liver Diseases Laboratory, CIC bioGUNE-BRTA, Derio, Spain

  https://orcid.org/0000-0002-6446-9911

  ⨯
• Ana M. Aransay,

  Roles Formal analysis, Writing – review & editing

  Affiliations Genomic Analysis Platform, CIC bioGUNE-BRTA, Derio, Spain, CIBERehd, Instituto de Salud Carlos III, Madrid, Spain

  https://orcid.org/0000-0002-8271-612X

  ⨯
• Alberto Pascual,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain

  https://orcid.org/0000-0001-5459-6207

  ⨯
• Felix Elortza,

  Roles Formal analysis, Writing – review & editing

  Affiliation Proteomics Platform, ProteoRed-ISCIII, CIC bioGUNE-BRTA, Derio, Spain

  https://orcid.org/0000-0001-8839-5438

  ⨯
• Edurne Berra,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Physiopathology of the Hypoxia-Signaling Pathway Laboratory, CIC bioGUNE-BRTA, Derio, Spain

  https://orcid.org/0000-0002-3820-5744

  ⨯
• José Luis Lavín,

  Roles Formal analysis, Writing – review & editing

  Current address: Neiker, Instituto Vasco de Investigación y Desarrollo Agrario-BRTA, Derio, Spain

  Affiliation Bioinformatics Service, CIC bioGUNE-BRTA, Derio, Spain

  https://orcid.org/0000-0003-0914-3211

  ⨯
• Héctor Rodríguez,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain

  https://orcid.org/0000-0002-9948-2497

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•  [ ... ],
• Juan Anguita

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Visualization, Writing – original draft

  * E-mail: janguita@cicbiogune.es

  Affiliations Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain, Ikerbasque, Basque Foundation for Science, Bilbao, Spain

  https://orcid.org/0000-0003-2061-7182

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