The E3 ubiquitin ligase Cul4b promotes CD4⁺ T cell expansion by aiding the repair of damaged DNA

• Asif A. Dar,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Division of Protective Immunity, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

  ⨯
• Keisuke Sawada,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Division of Protective Immunity, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

  ⨯
• Joseph M. Dybas,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliations Division of Protective Immunity, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Biomedical Health and Informatics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

  ⨯
• Emily K. Moser,

  Roles Data curation, Formal analysis, Visualization, Writing – review & editing

  Affiliation Division of Protective Immunity, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

  ⨯
• Emma L. Lewis,

  Roles Conceptualization, Data curation, Formal analysis, Writing – review & editing

  Affiliation Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-2572-1002

  ⨯
• Eddie Park,

  Roles Formal analysis, Writing – review & editing

  Affiliation Center for Computational and Genomic Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0001-5651-1481

  ⨯
• Hossein Fazelinia,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Division of Cell Pathology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

  ⨯
• Lynn A. Spruce,

  Roles Conceptualization, Data curation, Writing – review & editing

  Affiliation Division of Cell Pathology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0001-9640-9158

  ⨯
• Hua Ding,

  Roles Data curation, Writing – review & editing

  Affiliation Division of Cell Pathology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0001-5897-0534

  ⨯
• Steven H. Seeholzer,

  Roles Data curation, Supervision, Writing – review & editing

  Affiliation Division of Cell Pathology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0001-5243-7667

  ⨯
• Paula M. Oliver

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: paulao@pennmedicine.upenn.edu

  Affiliations Division of Protective Immunity, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-0455-3767

  ⨯