Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides

• Alexander M. Kloosterman,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Institute of Biology, Leiden University, the Netherlands

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• Peter Cimermancic ,

  Contributed equally to this work with: Peter Cimermancic, Somayah S. Elsayed

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Writing – review & editing

  Affiliation Verily Life Sciences, South San Francisco, CA, United States of America

  https://orcid.org/0000-0002-2802-7649

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• Somayah S. Elsayed ,

  Contributed equally to this work with: Peter Cimermancic, Somayah S. Elsayed

  Roles Formal analysis, Investigation, Methodology

  Affiliation Institute of Biology, Leiden University, the Netherlands

  https://orcid.org/0000-0003-3837-6137

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• Chao Du,

  Roles Formal analysis, Investigation

  Affiliation Institute of Biology, Leiden University, the Netherlands

  https://orcid.org/0000-0003-3447-5293

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• Michalis Hadjithomas,

  Roles Formal analysis, Investigation, Methodology, Software

  Current address: LifeMine Therapeutics, Cambridge, Massachusetts, United States of America

  Affiliation DOE Joint Genome Institute, Walnut Creek, CA, United States of America

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• Mohamed S. Donia,

  Roles Conceptualization, Investigation, Methodology

  Affiliation Department of Molecular Biology, Princeton University, NJ, United States of America

  https://orcid.org/0000-0002-9604-2912

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• Michael A. Fischbach,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision

  Affiliation Department of Bioengineering, Stanford University, CA, United States of America

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• Gilles P. van Wezel ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: g.wezel@biology.leidenuniv.nl (GPvW); marnix.medema@wur.nl (MHM)

  Affiliations Institute of Biology, Leiden University, the Netherlands, Netherlands Institute for Ecology (NIOO-KNAW), Wageningen, the Netherlands

  https://orcid.org/0000-0003-0341-1561

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• Marnix H. Medema

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: g.wezel@biology.leidenuniv.nl (GPvW); marnix.medema@wur.nl (MHM)

  Affiliation Bioinformatics group, Wageningen University, the Netherlands

  https://orcid.org/0000-0002-2191-2821

  ⨯