Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma

• Tsan-Wen Lu,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America

  ⨯
• Phillip C. Aoto,

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Department of Pharmacology, University of California, San Diego, La Jolla, California, United States of America

  https://orcid.org/0000-0001-6518-0899

  ⨯
• Jui-Hung Weng,

  Roles Data curation, Formal analysis, Validation, Visualization

  Affiliation Department of Pharmacology, University of California, San Diego, La Jolla, California, United States of America

  https://orcid.org/0000-0002-0432-3515

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• Cole Nielsen,

  Roles Data curation, Formal analysis

  Affiliation Department of Pharmacology, University of California, San Diego, La Jolla, California, United States of America

  https://orcid.org/0000-0003-1263-9816

  ⨯
• Jennifer N. Cash,

  Roles Validation, Writing – review & editing

  Affiliation Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0002-0277-7652

  ⨯
• James Hall,

  Roles Data curation

  Affiliation Department of Pharmacology, University of California, San Diego, La Jolla, California, United States of America

  https://orcid.org/0000-0002-9843-7520

  ⨯
• Ping Zhang,

  Roles Data curation, Visualization

  Current address: National Cancer Institute, National Institute of Health, Frederick, Maryland, United States of America

  Affiliation Department of Pharmacology, University of California, San Diego, La Jolla, California, United States of America

  ⨯
• Sanford M. Simon,

  Roles Resources, Writing – review & editing

  Affiliation Laboratory of Cellular Biophysics, The Rockefeller University, New York, New York, United States of America

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• Michael A. Cianfrocco ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mcianfro@umich.edu (MAC); staylor@ucsd.edu (SST)

  Affiliation Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Susan S. Taylor

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mcianfro@umich.edu (MAC); staylor@ucsd.edu (SST)

  Affiliations Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America, Department of Pharmacology, University of California, San Diego, La Jolla, California, United States of America

  https://orcid.org/0000-0002-7702-6108

  ⨯