Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

• Chaoyi Xu ,

  Contributed equally to this work with: Chaoyi Xu, Douglas K. Fischer, Sanela Rankovic

  Roles Conceptualization, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, United States of America, Pittsburgh Center for HIV Protein Interactions (PCHPI), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-9870-4297

  ⨯
• Douglas K. Fischer ,

  Contributed equally to this work with: Chaoyi Xu, Douglas K. Fischer, Sanela Rankovic

  Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Pittsburgh Center for HIV Protein Interactions (PCHPI), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-8267-6308

  ⨯
• Sanela Rankovic ,

  Contributed equally to this work with: Chaoyi Xu, Douglas K. Fischer, Sanela Rankovic

  Roles Formal analysis, Investigation, Visualization

  Affiliation Department of Physiology and Cell Biology, Ben-Gurion University of Negev, Beer Sheva, Israel

  https://orcid.org/0000-0001-9448-6037

  ⨯
• Wen Li,

  Roles Investigation, Visualization

  Affiliations Pittsburgh Center for HIV Protein Interactions (PCHPI), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Robert A. Dick,

  Roles Funding acquisition, Investigation, Visualization, Writing – original draft

  Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

  ⨯
• Brent Runge,

  Roles Investigation, Visualization

  Affiliations Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, United States of America, Pittsburgh Center for HIV Protein Interactions (PCHPI), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0003-3759-5143

  ⨯
• Roman Zadorozhnyi,

  Roles Investigation, Visualization

  Affiliations Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, United States of America, Pittsburgh Center for HIV Protein Interactions (PCHPI), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Jinwoo Ahn,

  Roles Funding acquisition, Investigation, Resources, Writing – original draft

  Affiliations Pittsburgh Center for HIV Protein Interactions (PCHPI), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Christopher Aiken,

  Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

  Affiliations Pittsburgh Center for HIV Protein Interactions (PCHPI), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

  ⨯
• Tatyana Polenova,

  Roles Funding acquisition, Investigation, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, United States of America, Pittsburgh Center for HIV Protein Interactions (PCHPI), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-0346-1131

  ⨯
• Alan N. Engelman,

  Roles Funding acquisition, Investigation, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Pittsburgh Center for HIV Protein Interactions (PCHPI), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-9709-2591

  ⨯
• Zandrea Ambrose ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: zaa4@pitt.edu (ZA); roussoi@bgu.ac.il (IR); jperilla@udel.edu (JRP)

  Affiliations Pittsburgh Center for HIV Protein Interactions (PCHPI), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-8610-2766

  ⨯
• Itay Rousso ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: zaa4@pitt.edu (ZA); roussoi@bgu.ac.il (IR); jperilla@udel.edu (JRP)

  Affiliation Department of Physiology and Cell Biology, Ben-Gurion University of Negev, Beer Sheva, Israel

  https://orcid.org/0000-0002-4399-9171

  ⨯
• Juan R. Perilla

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: zaa4@pitt.edu (ZA); roussoi@bgu.ac.il (IR); jperilla@udel.edu (JRP)

  Affiliations Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, United States of America, Pittsburgh Center for HIV Protein Interactions (PCHPI), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0003-1171-6816

  ⨯